Breese G R, Coyle S, Frye G D, Mueller R A
Pharmacol Biochem Behav. 1985 Jun;22(6):1013-8. doi: 10.1016/0091-3057(85)90311-9.
Investigations were undertaken with 5,7-dihydroxytryptamine and 6-hydroxydopamine treated rats to see whether activity changes induced by TRH, ethanol and the TRH-ethanol combination would be affected after reduced monoamine function. In keeping with earlier results, TRH increased activity, ethanol reduced activity and the TRH-ethanol combination produced activity counts greater than those for TRH alone. Neither the 5,7-dihydroxytryptamine-induced reduction of brain serotonin nor the 6-hydroxydopamine treatments which reduced brain catecholamines altered the hyperactivity induced by TRH or the TRH-ethanol combination. While reduction of brain serotonin did not affect the ethanol-induced changes in activity, preferential reduction of dopamine as well as reduction of both norepinephrine and dopamine significantly antagonized this measure of ethanol-induced depression. The reduction of dopamine alone produced the greatest effect on this action of ethanol. It can be concluded from the data that the increased locomotion induced by TRH and the TRH-ethanol combination does not depend upon endogenous monoamines, whereas the sedative effects of ethanol are apparently influenced by alterations in brain catecholamine function.
对用5,7 - 二羟基色胺和6 - 羟基多巴胺处理过的大鼠进行了研究，以观察在单胺功能降低后，促甲状腺激素释放激素（TRH）、乙醇以及TRH - 乙醇组合所诱导的活动变化是否会受到影响。与早期结果一致，TRH增加活动，乙醇降低活动，且TRH - 乙醇组合产生的活动计数大于单独使用TRH时的计数。5,7 - 二羟基色胺诱导的脑血清素减少以及6 - 羟基多巴胺处理导致的脑儿茶酚胺减少，均未改变TRH或TRH - 乙醇组合所诱导的多动。虽然脑血清素的减少并未影响乙醇诱导的活动变化，但多巴胺的选择性减少以及去甲肾上腺素和多巴胺两者的减少均显著拮抗了这种乙醇诱导的抑制作用。单独多巴胺的减少对乙醇的这一作用产生的影响最大。从这些数据可以得出结论，TRH和TRH - 乙醇组合所诱导的运动增加并不依赖于内源性单胺，而乙醇的镇静作用显然受脑儿茶酚胺功能改变的影响。
