Bielfeld Alexandra Petra, Baston-Buest Dunja Maria, Edimiris Philippos, Kruessel Jan-Steffen
Department of Obstetrics/Gynecology and Reproductive Endocrinology and Infertility (UniKiD), University of Duesseldorf Medical Center, Moorenstrasse 5, 40225 Duesseldorf, Germany.
J Clin Med. 2024 Aug 25;13(17):5024. doi: 10.3390/jcm13175024.
: In this observational prospective cohort study, conducted at the Fertility Centre of the University Hospital, Duesseldorf Germany, the spontaneous reversal capacity and the effect of waiting time on an adverse vaginal microbiome profile in subfertile patients were investigated. : Vaginal swabs of 76 patients were obtained before starting a fertility treatment using a commercially available test to perform a microbiome analysis. Patients with a favorable microbiome profile ("medium" or "high profile") according to the manufacturer's algorithm proceeded with the fertility treatment. Patients with an unfavorable microbiome profile ("low profile") postponed their fertility treatment and were sampled up to four times in each successive cycle or until a shift to a more favorable profile was detected. : Initially, 54/76 subjects had a high or medium profile and 23/76 had a low profile. Within 3 months, 75% of patients with an initial low profile shifted to a more favorable profile (7/23 dropouts). The presence of in the initial sample was associated with a higher likelihood of a spontaneous shift to a more favorable profile. : The vaginal microbiome is subject to strong fluctuations. Even an unfavorable microbiome profile can develop into a favorable microbiome profile within a few months without treatment.
在德国杜塞尔多夫大学医院生育中心进行的这项观察性前瞻性队列研究中，研究了亚生育患者阴道微生物群不良状况下的自然逆转能力以及等待时间的影响。在开始生育治疗前，使用市售检测方法获取76名患者的阴道拭子以进行微生物群分析。根据制造商算法，微生物群状况良好（“中等”或“高等”）的患者继续进行生育治疗。微生物群状况不佳（“低等”）的患者推迟生育治疗，并在每个连续周期中采样多达四次，或直至检测到转变为更有利的状况。最初，54/76名受试者状况为高等或中等，23/76名受试者状况为低等。在3个月内，75%初始状况为低等的患者转变为更有利的状况（7/23名退出研究）。初始样本中存在[此处原文缺失相关内容]与自然转变为更有利状况的可能性较高相关。阴道微生物群波动很大。即使微生物群状况不佳，未经治疗也可能在几个月内发展为良好的微生物群状况。
