Söğütlü Yakup, Altaş Uğur
Ümraniye Training and Research Hospital, Department of Pediatrics, Pediatric Emergency Medicine Clinic, University of Health Sciences, 34764 İstanbul, Türkiye.
Ümraniye Training and Research Hospital, Department of Pediatrics, Pediatric Allergy and Immunology Clinic, University of Health Sciences, 34764 İstanbul, Türkiye.
J Clin Med. 2024 Sep 9;13(17):5330. doi: 10.3390/jcm13175330.
There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte-platelet ratio (NLPR), and pan-immune-inflammation value (PIV) in febrile seizure. A total of 300 children, including 100 with febrile convulsions (FS), 100 febrile controls (FCs), and 100 healthy controls (HCs), were included in this retrospective study. The FS group was compared with the FC and HC groups in terms of these inflammatory indexes. Between the FS group and the FC group, the neutrophil count was significantly higher in the FS group ( = 0.001) and the lymphocyte count was significantly lower ( < 0.001). The NLR ( < 0.001), SII ( < 0.001), SIRI ( < 0.001), NLPR ( < 0.001), and PIV ( < 0.001) were significantly higher in the FS group than in both the FC and healthy control groups. The optimal cut-off values for predicting FS in febrile conditions were 3.59> for NLR, >870.47 for SII, >1.96 for SIRI, 0.96> for NLPR, and >532.75 for PIV. The inflammatory indices are inexpensive, easily accessible hematological markers that can contribute to the diagnosis of FS.
越来越多的证据表明炎症对热性惊厥（FS）患者的病因有影响。我们旨在研究易于获取的炎症标志物，如中性粒细胞与淋巴细胞比值（NLR）、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）、中性粒细胞-淋巴细胞-血小板比值（NLPR）和全免疫炎症值（PIV）在热性惊厥中的作用。这项回顾性研究共纳入了300名儿童，包括100名热性惊厥（FS）患儿、100名发热对照（FC）儿童和100名健康对照（HC）儿童。在这些炎症指标方面，将FS组与FC组和HC组进行了比较。在FS组和FC组之间，FS组的中性粒细胞计数显著更高（ = 0.001），而淋巴细胞计数显著更低（ < 0.001）。FS组的NLR（ < 0.001）、SII（ < 0.001）、SIRI（ < 0.001）、NLPR（ < 0.001）和PIV（ < 0.001）均显著高于FC组和健康对照组。在发热情况下预测FS的最佳截断值为：NLR > 3.59，SII > 870.47，SIRI > 1.96，NLPR > 0.96，PIV > 532.75。这些炎症指标是廉价且易于获取的血液学标志物，有助于FS的诊断。
