Skrifvars B
Scand J Rheumatol. 1979;8(4):241-7. doi: 10.3109/03009747909114630.
Renal biopsy specimens from 20 patients, 14 women and 6 men, with rheumatoid arthritis (RA) of at least 6 months' duration were studied by direct immunofluorescence microscopy for the presence of immune deposits. Pathological changes were most prominent in patients with longstanding or malignant disease and in patients previously on gold salt therapy. Staining for IgG and C3 was negative in 4 patients with an arthritis of 2 year's duration or less. Fifteen patients had glomerular deposits containing IgG or C3, or both. In 6 of these patients staining was also positive for IgM and in 3 for IgA. In 8 patients C3 was distributed in irregular deposits along the tubular basement membrane. These results suggest that in patients with RA, immunological processes have an untoward effect on the kidneys. The long-term effects of these processes might contribute, moreover, to the development of late renal complications. There is no evidence, however, that the renal immune deposits documented so frequently in this study derive from the rheumatoid disease itself.
对20例类风湿关节炎（RA）患者（14名女性和6名男性）病程至少6个月的肾活检标本进行直接免疫荧光显微镜检查，以确定是否存在免疫沉积物。病理变化在长期或恶性疾病患者以及先前接受金盐治疗的患者中最为明显。4例病程为2年或更短的关节炎患者的IgG和C3染色为阴性。15例患者的肾小球沉积物中含有IgG或C3，或两者皆有。其中6例患者的IgM染色也呈阳性，3例患者的IgA染色呈阳性。8例患者的C3沿肾小管基底膜呈不规则沉积物分布。这些结果表明，在RA患者中，免疫过程对肾脏有不良影响。此外，这些过程的长期影响可能会导致晚期肾脏并发症的发生。然而，没有证据表明本研究中如此频繁记录到的肾免疫沉积物源自类风湿疾病本身。
