Bergin C J, Müller N L
AJR Am J Roentgenol. 1985 Sep;145(3):505-10. doi: 10.2214/ajr.145.3.505.
The computed tomographic (CT) appearance of interstitial lung disease was assessed in 23 patients with known interstitial disease. These included seven patients with fibrosing alveolitis, six with silicosis, two with hypersensitivity pneumonitis, three with lymphangitic spread of tumor, two with sarcoidosis, one with rheumatoid lung disease, and two with neurofibromatosis. The CT appearance of the interstitial changes in the different disease entities was assessed. Nodules were a prominent CT feature in silicosis, sarcoidosis, and lymphangitic spread of malignancy. Distribution of nodules and associated interlobular septal thickening provided further distinguishing features in these diseases. Reticular densities were the predominant CT change in fibrosing alveolitis, rheumatoid lung disease, and extrinsic allergic alveolitis. A marked peripheral predominance of the interstitial densities was seen in all seven cases of fibrosing alveolitis and in the patient with rheumatoid lung, in marked contrast with the two cases of hypersensitivity pneumonitis in whom a central distribution of the changes was seen. The observed patterns correlate with the pathologic findings and provide information that at times cannot be obtained from the chest radiograph. CT can be useful in the investigation of selected instances of interstitial pulmonary disease.
对23例已知间质性疾病患者的间质性肺病的计算机断层扫描（CT）表现进行了评估。其中包括7例纤维化肺泡炎患者、6例矽肺患者、2例过敏性肺炎患者、3例肿瘤淋巴管播散患者、2例结节病患者、1例类风湿性肺病患者和2例神经纤维瘤病患者。评估了不同疾病实体中间质性改变的CT表现。结节是矽肺、结节病和恶性肿瘤淋巴管播散的突出CT特征。结节的分布及相关的小叶间隔增厚为这些疾病提供了进一步的鉴别特征。网状密度是纤维化肺泡炎、类风湿性肺病和外源性过敏性肺泡炎的主要CT改变。在所有7例纤维化肺泡炎患者及类风湿性肺病患者中，均可见明显的间质密度外周优势，这与2例过敏性肺炎患者中所见的病变中央分布形成显著对比。观察到的模式与病理结果相关，并提供了有时从胸部X线片无法获得的信息。CT在某些间质性肺病病例的检查中可能有用。
