Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.
Int J Pharm. 2024 Nov 15;665:124701. doi: 10.1016/j.ijpharm.2024.124701. Epub 2024 Sep 13.
Melanoma is a prevalent and concerning form of skin cancer affecting millions of individuals worldwide. Unfortunately, traditional treatments can be invasive and painful, prompting the need for alternative therapies with improved efficacy and patient outcomes. Nanosystems offer a promising solution to these obstacles through the rational design of nanoparticles (NPs) which are structured into nanocomposite forms, offering efficient approaches to cancer treatment procedures. A range of NPs consisting of polymeric, metallic and metal oxide, carbon-based, and virus-like NPs have been studied for their potential in treating skin cancer. This review summarizes the latest developments in functional nanosystems aimed at enhancing melanoma treatment. The fundamentals of these nanosystems, including NPs and the creation of various functional nanosystem types, facilitating melanoma treatment are introduced. Then, the advances in the applications of functional nanosystems for melanoma treatment are summarized, outlining both their benefits and the challenges encountered in implementing nanosystem therapies.
黑色素瘤是一种常见且令人担忧的皮肤癌形式，影响着全球数百万人。不幸的是，传统治疗方法可能具有侵入性和痛苦，因此需要具有更好疗效和患者结果的替代疗法。纳米系统通过合理设计纳米粒子（NPs）为这些障碍提供了有希望的解决方案，这些 NPs 被构建成纳米复合材料形式，为癌症治疗方法提供了有效的途径。已经研究了一系列由聚合物、金属和金属氧化物、基于碳和类似病毒的 NPs 组成的 NPs，以探索其在治疗皮肤癌方面的潜力。这篇综述总结了旨在增强黑色素瘤治疗的功能纳米系统的最新进展。介绍了这些纳米系统的基本原理，包括 NPs 和各种功能纳米系统类型的创建，这些系统有助于黑色素瘤的治疗。然后，总结了功能纳米系统在黑色素瘤治疗中的应用进展，概述了纳米系统疗法的益处和遇到的挑战。
