Kalter H
Teratology. 1979 Oct;20(2):213-32. doi: 10.1002/tera.1420200206.
The A family of inbred mice which originated in 1921, came during its early development to have incorporated into its genome the tendency to several congenital malformations, among them cleft lip and palate. These sporadic abnormalities are of interest because they closely resemble their human counterparts in morphology and development, and because they share with them a multifactorial basis. The origins and development of the A family are traced, and the abnormalities are described and the forces affecting them detailed.
起源于1921年的近交系A小鼠家族，在其早期发育过程中，其基因组中融入了几种先天性畸形的倾向，其中包括唇腭裂。这些散发性异常之所以令人感兴趣，是因为它们在形态和发育上与人类的对应异常非常相似，而且它们与人类异常一样具有多因素基础。本文追溯了A家族的起源和发展，描述了这些异常情况，并详细阐述了影响它们的因素。
