视力损害全球负担与环境大气细颗粒物的相关性
The Correlation of Global Burden of Vision Impairment and Ambient Atmospheric Fine Particulate Matter.
作者信息
Abdolalizadeh Parya, Falavarjani Khalil Ghasemi
机构信息
Department of Ophthalmology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
出版信息
J Curr Ophthalmol. 2024 Aug 10;35(4):387-394. doi: 10.4103/joco.joco_125_23. eCollection 2023 Oct-Dec.
PURPOSE
To assess the correlation between the worldwide burden of vision impairment (VI) and fine particulate matter (PM) 2.5.
METHODS
In this retrospective cross-sectional study, global and national prevalence and disability-adjusted lost year (DALY) numbers and rates of total VI, glaucoma, cataract, and age-related macular degeneration (AMD) were obtained from the Global Burden of Disease database. The global and national levels of PM2.5 levels were also extracted. The main outcome measures were the correlation of PM2.5 levels with total VI and three ocular diseases in different age, sex, and socioeconomic subgroups.
RESULTS
In 2019, the worldwide prevalence of total VI and exposure level of PM2.5 was 9.6% (95% uncertainty interval: 8.0-11.3) and 42.5 μg/m, respectively. The national age-standardized prevalence rates of total VI ( = 0.52, < 0.001), glaucoma ( = 0.65, < 0.001), AMD ( = 0.67, < 0.001), and cataract ( = 0.44, < 0.001) have a positive correlation with PM2.5 levels. In addition, the national age-standardized DALY rates of total VI ( = 0.62, < 0.001), glaucoma ( = 0.62, < 0.001), AMD ( = 0.54, < 0.001), and cataract ( = 0.45, < 0.001) significantly correlated with PM2.5 levels. The correlations remained significant in different age, sex, and sociodemographic subgroups.
CONCLUSION
National prevalence rates of VI and three major ocular diseases correlate significantly with PM2.5 exposure levels, worldwide.
目的
评估全球视力损害（VI）负担与细颗粒物（PM）2.5之间的相关性。
方法
在这项回顾性横断面研究中，从全球疾病负担数据库中获取全球和国家层面的患病率、残疾调整生命年（DALY）数量以及全视力损害、青光眼、白内障和年龄相关性黄斑变性（AMD）的发生率。同时提取全球和国家层面的PM2.5水平。主要结局指标为不同年龄、性别和社会经济亚组中PM2.5水平与全视力损害及三种眼部疾病的相关性。
结果
2019年，全球全视力损害患病率和PM2.5暴露水平分别为9.6%（95%不确定区间：8.0 - 11.3）和42.5μg/m³。全视力损害（r = 0.52，P < 0.001）、青光眼（r = 0.65，P < 0.001）、AMD（r = 0.67，P < 0.001）和白内障（r = 0.44，P < 0.001）的国家年龄标准化患病率与PM2.5水平呈正相关。此外，全视力损害（r = 0.62，P < 0.001）、青光眼（r = 0.62，P < 0.001）、AMD（r = 0.54，P < 0.001）和白内障（r = 0.45，P < 0.001）的国家年龄标准化DALY率与PM2.5水平显著相关。在不同年龄、性别和社会人口亚组中，这种相关性仍然显著。
结论
全球范围内，视力损害及三种主要眼部疾病的国家患病率与PM2.5暴露水平显著相关。
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