Andrade Diana de Medeiros, Oliveira Jordane Benedito Vargas, Lacordia Marta Halfeld Ferrari Alves, Laterza Mateus Camaroti, Martinez Daniel Godoy
Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Ophthalmology Service of the University Hospital of the Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
J Curr Ophthalmol. 2024 Aug 10;35(4):320-325. doi: 10.4103/joco.joco_207_23. eCollection 2023 Oct-Dec.
To compare the ocular perfusion pressure (OPP) response during physical exercise in individuals with and without a family history (FH+, FH-) of glaucoma.
Thirty-four subjects, divided into FH+ and FH- groups, realized 3 min at rest, 3 min of isometric handgrip exercise at 30% of maximal voluntary contraction, followed by 3 min of recovery. Blood pressure (Dixtal automatic device) and intraocular pressure (Goldmann applanation tonometer) were measured during rest, exercise, and recovery. The mean OPP (mOPP) was calculated.
In the FH+ group (17 subjects), baseline mOPP values were significantly lower than in the FH- group (17 subjects) (right eye: < 0.001, left eye: < 0.001, respectively). During exercise, both the FH+ and FH- groups showed a similar increase in mOPP in both eyes (right eye: FH+: 38 ± 4 mmHg vs. 51 ± 7 mmHg, FH-: 48 ± 5 mmHg vs. 57 ± 9 mmHg, < 0.001; left eye: FH+: 39 ± 3 mmHg vs. 51 ± 7 mmHg; FH-: 46 ± 5 mmHg vs. 58 ± 8 mmHg, < 0.001, respectively). However, the FH+ group maintained significantly lower mOPP values compared to the FH- group in the right and left eyes (group effect: = 0.002, = 0.002, respectively). The percentage of increase in mOPP in the FH+ group was greater compared to the FH- group during exercise (right eye: 34.1% ± 15.9% vs. 22.1% ± 13.2%, respectively; = 0.025; left eye: 33.2% ± 17.7% vs. 22.4% ± 13.7%, respectively, = 0.056).
mOPP increased during physical exercise in both groups, but the FH+ group had lower absolute values. In addition, the FH+ group appears to demonstrate a higher percentage increase in mOPP compared to the FH- group.
比较有青光眼家族史（FH+）和无青光眼家族史（FH-）的个体在体育锻炼期间的眼灌注压（OPP）反应。
34名受试者分为FH+组和FH-组，先静息3分钟，然后以最大自主收缩力的30%进行3分钟等长握力运动，随后恢复3分钟。在静息、运动和恢复期间测量血压（Dixtal自动装置）和眼压（Goldmann压平眼压计）。计算平均眼灌注压（mOPP）。
在FH+组（17名受试者）中，基线mOPP值显著低于FH-组（17名受试者）（右眼：<0.001，左眼：<0.001）。运动期间，FH+组和FH-组双眼的mOPP均有相似程度的升高（右眼：FH+组：38±4 mmHg对51±7 mmHg，FH-组：48±5 mmHg对57±9 mmHg，<0.001；左眼：FH+组：39±3 mmHg对51±7 mmHg；FH-组：46±5 mmHg对58±8 mmHg，<0.001）。然而，与FH-组相比，FH+组双眼的mOPP值仍显著较低（组效应：右眼=0.002，左眼=0.002）。运动期间，FH+组mOPP的升高百分比高于FH-组（右眼：分别为34.1%±15.9%对22.1%±13.2%，P=0.025；左眼：分别为33.2%±17.7%对22.4%±13.7%，P=0.056）。
两组在体育锻炼期间mOPP均升高，但FH+组的绝对值较低。此外，与FH-组相比，FH+组mOPP的升高百分比似乎更高。
