Kang Jea Woo, Khatib Lora A, Heston Margo B, Dilmore Amanda H, Labus Jennifer S, Deming Yuetiva, Schimmel Leyla, Blach Colette, McDonald Daniel, Gonzalez Antonio, Bryant MacKenzie, Sanders Karenina, Schwartz Ara, Ulland Tyler K, Johnson Sterling C, Asthana Sanjay, Carlsson Cynthia M, Chin Nathaniel A, Blennow Kaj, Zetterberg Henrik, Rey Federico E, Kaddurah-Daouk Rima, Knight Rob, Bendlin Barbara B
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA Address: 600 Highland Ave, J5/1 Mezzanine, Madison, WI, USA 53792.
Department of Pediatrics, University of California San Diego, La Jolla, California, USA Address: 9461 Gilman Dr, La Jolla, CA, USA 92093.
medRxiv. 2024 Sep 5:2024.09.04.24313004. doi: 10.1101/2024.09.04.24313004.
The gut microbiome is a potentially modifiable factor in Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited.
Shallow-shotgun metagenomic data was used to analyze fecal microbiome from participants enrolled in the Wisconsin Microbiome in Alzheimer's Risk Study, leveraging clinical data and cerebrospinal fluid (CSF) biomarkers. Differential abundance and ordinary least squares regression analyses were performed to find differentially abundant gut microbiome features and their associations with CSF biomarkers of AD and related pathologies.
Gut microbiome composition and function differed between people with AD and cognitively unimpaired individuals. The compositional difference was replicated in an independent cohort. Differentially abundant gut microbiome features were associated with CSF biomarkers of AD and related pathologies.
These findings enhance our understanding of alterations in gut microbial composition and function in AD, and suggest that gut microbes and their pathways are linked to AD pathology.
肠道微生物群是阿尔茨海默病（AD）中一个潜在的可调节因素；然而，关于其在AD病理学方面的组成和功能的了解有限。
利用来自威斯康星州阿尔茨海默病风险研究中参与者的粪便微生物群的浅鸟枪法宏基因组数据，结合临床数据和脑脊液（CSF）生物标志物。进行差异丰度分析和普通最小二乘回归分析，以发现差异丰富的肠道微生物群特征及其与AD及相关病理学的CSF生物标志物的关联。
AD患者与认知未受损个体的肠道微生物群组成和功能存在差异。这种组成差异在一个独立队列中得到了重复。差异丰富的肠道微生物群特征与AD及相关病理学的CSF生物标志物相关。
这些发现增强了我们对AD中肠道微生物组成和功能改变的理解，并表明肠道微生物及其途径与AD病理学有关。
