Fatsi Patrick Senam Kofi, Kawai Koichiro, Asmah Ruby, Oppong Betty Bandoh, Appiah Ebenezer Koranteng, Hashem Shaharior, Addo Acheampong, Kusorgbor Joyce Kplorla, Magna Emmanuel Kaboja, Obeng Abraham Kusi, Quansah Lydia, Saba Courage Kosi Setsoafia, Bawah Juliana, Setufe Seyramsarah Blossom, Adu-Nti Frank, Ameworwor Miriam Yayra, Quansah Clara Ruth, Saito Hidetoshi, Johnson-Ashun Mercy, Osei Lilly Konadu, Agbeko Etornyo, Anani Francis Assogba, Agyakwah Seth Koranteng
Department of Bioresource Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashihiroshima, 739-8528 Japan.
Council for Scientific and Industrial Research - Water Research Institute, P. O. Box M 32, Accra, Ghana.
Indian J Microbiol. 2024 Sep;64(3):1110-1122. doi: 10.1007/s12088-024-01254-1. Epub 2024 Mar 30.
The common use of antimicrobials in food-animal production can lead to drug residues in edible tissues for consumers. However, immunomodulators enhance immune responses and vaccine effectiveness. A new perspective explores bacterial extracellular bioactive molecules (EBMs) in food-animal production to modulate host immune responses, potentially transforming pathogen management and antimicrobial use. This study investigates the immunogenic potential of -derived EBMs (Antigens) to enhance the immune system. Four Antigens were administered intraperitoneally to (Nile Tilapia). Antigens 2 and Antigens 3 boosted fish immune competence within 21 days. Remarkably, Antigens 3 induced robust immunity against . with a single dose, notably enhancing antibody-based immune responses. The increased antibody activity suggests Antigens 3 could be a vaccine candidate, promising further research and potential application in food-animal production to improve disease control. This study highlights immunomodulators' potential in reshaping disease management in the food-animal industry, emphasizing the benefits of focusing on bacterial EBMs to reduce reliance on antimicrobials and achieve sustainable disease prevention.
在食用动物生产中普遍使用抗菌药物会导致消费者食用的组织中出现药物残留。然而，免疫调节剂可增强免疫反应和疫苗效力。一个新的视角探索了食用动物生产中细菌的细胞外生物活性分子（EBMs），以调节宿主免疫反应，这可能会改变病原体管理和抗菌药物的使用方式。本研究调查了源自[具体名称未提及]的EBMs（抗原）增强免疫系统的免疫原性潜力。将四种抗原腹腔注射给尼罗罗非鱼。抗原2和抗原3在21天内增强了鱼类的免疫能力。值得注意的是，抗原3单剂量就能诱导针对[具体病原体未提及]的强大免疫力，显著增强基于抗体的免疫反应。抗体活性的增加表明抗原3可能是一种疫苗候选物，有望在食用动物生产中进行进一步研究和潜在应用，以改善疾病控制。本研究突出了免疫调节剂在重塑食用动物行业疾病管理方面的潜力，强调了专注于细菌EBMs以减少对抗菌药物的依赖并实现可持续疾病预防的益处。
