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IL-4/13 Blockade and sleep-related adverse drug reactions in over 37,000 Dupilumab reports from the World Health Organization Individual Case Safety reporting pharmacovigilance database (VigiBase™): a big data and machine learning analysis.IL-4/13 阻断剂与超过 37000 例度普利尤单抗报告中的睡眠相关药物不良反应：来自世界卫生组织个体病例安全报告药物警戒数据库（VigiBase™）的大数据和机器学习分析。
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T Helper 2 IL-4/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17‒Type Diseases, Including Seronegative Arthritis and Enthesitis/Enthesopathy, but Not to Humoral Autoimmune Diseases.度普利尤单抗（Dupilumab）阻断辅助性 T 细胞 2（Th2）细胞白细胞介素 4/白细胞介素 13（IL-4/IL-13）通路与某些新发的 Th17 型疾病相关，包括血清阴性关节炎和肌腱端炎/肌腱病，但与体液自身免疫性疾病无关。
J Invest Dermatol. 2022 Oct;142(10):2660-2667. doi: 10.1016/j.jid.2022.03.013. Epub 2022 Apr 6.
4
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6
Dupilumab therapy of atopic dermatitis of the elderly: a multicentre, real-life study.度普利尤单抗治疗老年特应性皮炎：一项多中心、真实世界研究。
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7
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10
Approach to Patients with Eosinophilia.嗜酸粒细胞增多患者的处理方法。
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合并嗜酸性粒细胞增多会增加斑秃患者指甲异常的发生率和脱发的严重程度。

Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata.

作者信息

Damiani Giovanni, Gironi Laura Cristina, Conic Rosalynn R Z, Del Fabbro Massimo, Savoia Paola, Fiore Marco, Bergfeld Wilma F

机构信息

Italian Center of Precision Medicine and Chronic Inflammation University of Milan, Milan, Italy.

Department of Biomedical Surgical and Dental Sciences University of Milan, Milan, Italy.

出版信息

Biomed Res Int. 2024 Sep 7;2024:5596647. doi: 10.1155/2024/5596647. eCollection 2024.

DOI:10.1155/2024/5596647
PMID:39282571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11401657/
Abstract

The potential link between alopecia areata (AA) and eosinophilia is unclear, as well as its clinical manifestations in these patients' subsets. This is a monocentric retrospective observational study in which clinical and laboratory data were summarized and evaluated the AA subset with concurrent eosinophilia. In a sample of 205 AA patients, 38 (18.5%) were classified as AA with eosinophilia. Interestingly, this subset of patients had a statistically higher prevalence of atopia and nail abnormalities ( < 0.05) than AA without eosinophilia. AA patients with eosinophilia had a 3.70 higher odds of more severe hair loss versus age- and gender-matched AA without eosinophilia. AA patients with eosinophilia had distinctive clinical and laboratory characteristics, so future studies may potentially explore the use of IL-5 inhibitors.

摘要

斑秃（AA）与嗜酸性粒细胞增多之间的潜在联系尚不清楚，其在这些患者亚组中的临床表现也不明确。这是一项单中心回顾性观察研究，其中总结了临床和实验室数据，并对并发嗜酸性粒细胞增多的AA亚组进行了评估。在205例AA患者样本中，38例（18.5%）被归类为伴有嗜酸性粒细胞增多的AA。有趣的是，与无嗜酸性粒细胞增多的AA患者相比，该患者亚组的特应性和指甲异常患病率在统计学上更高（<0.05）。与年龄和性别匹配的无嗜酸性粒细胞增多的AA患者相比，伴有嗜酸性粒细胞增多的AA患者出现更严重脱发的几率高3.70倍。伴有嗜酸性粒细胞增多的AA患者具有独特的临床和实验室特征，因此未来的研究可能会探索白细胞介素-5抑制剂的应用。