Astaneh Mohammad Ebrahim, Hashemzadeh Alireza, Fereydouni Narges
Department of Anatomical Sciences, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
J Mater Chem B. 2024 Oct 17;12(40):10163-10197. doi: 10.1039/d4tb01049c.
Diabetic wounds pose a significant challenge in healthcare due to impaired healing and increased risk of complications. In recent years, various drug delivery systems with stimuli-responsive features have been developed to address these issues. These systems enable precise dosage control and tailored drug release, promoting comprehensive tissue repair and regeneration. This review explores targeted therapeutic agents, such as carboxymethyl chitosan-alginate hydrogel formulations, nanofiber mats, and core-shell nanostructures, for diabetic wound healing. Additionally, the integration of nanotechnology and multifunctional biomimetic scaffolds shows promise in enhancing wound healing outcomes. Future research should focus on optimizing the design, materials, and printing parameters of 3D-bio-printed wound dressings, as well as exploring combined strategies involving the simultaneous release of antibiotics and nitric oxide for improved wound healing.
糖尿病伤口由于愈合受损和并发症风险增加，给医疗保健带来了重大挑战。近年来，已开发出各种具有刺激响应特性的药物递送系统来解决这些问题。这些系统能够实现精确的剂量控制和定制的药物释放，促进全面的组织修复和再生。本综述探讨了用于糖尿病伤口愈合的靶向治疗剂，如羧甲基壳聚糖-海藻酸盐水凝胶制剂、纳米纤维垫和核壳纳米结构。此外，纳米技术与多功能仿生支架的结合在改善伤口愈合结果方面显示出前景。未来的研究应侧重于优化3D生物打印伤口敷料的设计、材料和打印参数，以及探索同时释放抗生素和一氧化氮以改善伤口愈合的联合策略。
