School of Biomedical Engineering, Universiti Teknologi Malaysia, UTM, 81310, Skudai, Johor, Malaysia.
Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000, Kangar, Perlis, Malaysia.
Adv Exp Med Biol. 2024;1457:33-44. doi: 10.1007/978-3-031-61939-7_2.
The whole world has lived in fear of the Coronavirus 2019 (COVID-19) for more than one-fourth of a year in 2020. Since then, numerous studies have been done and others are still being conducted to identify the coronavirus causal agent and determine the ideal antiviral therapies for treating this illness. Despite the fact of significant global efforts, which are being made to develop vaccines and identify therapeutic medicines, the emergence of multiple variants has rumbled the research for developing an ideal diagnostic and therapeutic tool for targeting COVID-19. A thorough anatomy of the coronavirus virus and its global dissemination is essential for healthcare initiatives, as well as for predicting and preventing new epidemics. Testing for active COVID-19 infections is a critical public health strategy for tracking the epidemic. The widespread adoption of polymerase chain reaction (PCR) and antigen rapid test assays has increased the supply of test kits. In this chapter, the significance of molecular technique to develop prognostic analytical techniques for targeting COVID-19 along with the advantages and limitations of available techniques is discussed.
2020 年，全世界已经在恐惧中度过了超过四分之一的时间，因为这种新型冠状病毒 2019（COVID-19）。自那时以来，已经进行了许多研究，并且仍在进行其他研究，以确定冠状病毒的病原体，并确定治疗这种疾病的理想抗病毒疗法。尽管全球正在做出巨大努力来开发疫苗和确定治疗药物，但多种变体的出现已经破坏了针对 COVID-19 开发理想诊断和治疗工具的研究。对冠状病毒及其全球传播的彻底剖析对于医疗保健计划以及预测和预防新的传染病至关重要。针对活动性 COVID-19 感染的检测是跟踪该流行病的一项重要公共卫生策略。聚合酶链反应（PCR）和抗原快速检测试验的广泛采用增加了检测试剂盒的供应。在本章中，讨论了分子技术在开发针对 COVID-19 的预测分析技术方面的重要性，以及现有技术的优缺点。
