Neurology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, 42122, Reggio Emilia, Italy.
Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, 42122, Reggio Emilia, Italy.
Adv Exp Med Biol. 2024;1457:111-123. doi: 10.1007/978-3-031-61939-7_6.
Coronavirus disease 2019 (COVID-19) has been associated with a variety of neurological manifestations (i.e., anosmia, ageusia, myalgia, headache) and neurological syndromes (i.e., encephalopathy, ischemic and hemorrhagic stroke, myelitis, encephalitis) underlying different pathogenetic mechanisms. COVID-19 has also been associated with various movement disorders including acute or subacute parkinsonism. However, to date, only few cases of parkinsonism linked to COVID-19 have been reported, nevertheless raising the possibility of a post-viral parkinsonian syndrome. Furthermore, various studies in vitro and in animal models have highlighted a close relationship between SARS-CoV-2 virus and α-synuclein, leading to the hypothesis that COVID-19 could represent a factor favoring the long-term development of α-synucleopathies. In this chapter, we will discuss the pathophysiological mechanisms related to movement disorders' manifestations of COVID-19 focusing on the possible overlap between pathogenetic mechanisms of Parkinson's Disease and COVID-19.
新型冠状病毒病 2019（COVID-19）与多种神经系统表现（即嗅觉丧失、味觉丧失、肌痛、头痛）和神经系统综合征（即脑病、缺血性和出血性中风、脊髓炎、脑炎）相关，这些表现和综合征的发病机制各不相同。COVID-19 还与多种运动障碍相关，包括急性或亚急性帕金森病。然而，迄今为止，仅报道了少数与 COVID-19 相关的帕金森病病例，但仍有可能是病毒性帕金森综合征。此外，体外和动物模型的各种研究强调了 SARS-CoV-2 病毒与α-突触核蛋白之间的密切关系，这使得人们假设 COVID-19 可能是促进α-突触核蛋白病长期发展的一个因素。在本章中，我们将讨论与 COVID-19 运动障碍表现相关的病理生理机制，重点关注帕金森病和 COVID-19 的发病机制之间可能存在的重叠。
