Mcketta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States.
Biomacromolecules. 2024 Oct 14;25(10):6319-6337. doi: 10.1021/acs.biomac.4c00835. Epub 2024 Sep 16.
Mesenchymal stromal cells (MSCs) have broad immunomodulatory properties that range from regulation, proliferation, differentiation, and immune cell activation to secreting bioactive molecules that inhibit inflammation and regulate immune response. These properties provide MSCs with high therapeutic potency that has been shown to be relevant to tissue engineering and regenerative medicine. Hence, researchers have explored diverse strategies to control the immunomodulatory potential of stromal cells using polymeric substrates or scaffolds. These substrates alter the immunomodulatory response of MSCs, especially through biophysical cues such as matrix mechanical properties. To leverage these cell-matrix interactions as a strategy for priming MSCs, emerging studies have explored the use of stimuli-responsive substrates to enhance the therapeutic value of stromal cells. This review highlights how stimuli-responsive materials, including chemo-responsive, microenvironment-responsive, magneto-responsive, mechano-responsive, and photo-responsive substrates, have specifically been used to promote the immunomodulatory potential of stromal cells by controlling their secretory activity.
间充质基质细胞（MSCs）具有广泛的免疫调节特性，包括调节、增殖、分化和免疫细胞激活，以及分泌抑制炎症和调节免疫反应的生物活性分子。这些特性使 MSCs 具有很高的治疗效力，这与组织工程和再生医学有关。因此，研究人员探索了使用聚合物基质或支架来控制基质细胞免疫调节潜力的各种策略。这些基质改变了 MSCs 的免疫调节反应，特别是通过基质机械特性等生物物理线索。为了利用这些细胞-基质相互作用作为启动 MSCs 的策略，新兴的研究探索了使用对刺激有反应的基质来提高基质细胞的治疗价值。本综述重点介绍了包括化学响应性、微环境响应性、磁响应性、力响应性和光响应性基质在内的刺激响应性材料如何通过控制其分泌活性来特异性地促进基质细胞的免疫调节潜力。
