CHU Bordeaux, Department of Ophthalmology, Bordeaux, France.
IHU Liryc, Electrophysiology and Heart Modeling Institute, Hôpital Xavier ArnozanPessac, France.
Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):3. doi: 10.1167/iovs.64.3.3.
The purpose of this study was to compare 24-hour intraocular pressure (IOP) related fluctuations monitoring between 2 groups of visual field progression rates in patients with open angle glaucoma (OAG).
Cross-sectional study performed at Bordeaux University Hospital. Twenty-four-hour monitoring was performed using a contact lens sensor (CLS; Triggerfish; SENSIMED, Etagnières, Switzerland). Progression rate was calculated using a linear regression of the mean deviation (MD) parameter of the visual field test (Octopus; HAAG-STREIT, Switzerland). Patients were allocated into two groups: group 1 with an MD progression rate <-0.5 dB/year and group 2 with an MD progression rate ≥-0.5 dB/year. An automatic signal-processing program was developed and a frequency filtering of the monitoring by wavelet transform analysis was used to compare the output signal between the two groups. A multivariate classifier was performed for prediction of the faster progression group.
Fifty-four eyes of 54 patients were included. The mean progression rate was -1.09 ± 0.60 dB/year in group 1 (n = 22) and -0.12 ± 0.13 dB/year in group 2 (n = 32). Twenty-four-hour magnitude and absolute area under the monitoring curve were significantly higher in group 1 than in group 2 (group 1: 343.1 ± 62.3 millivolts [mVs] and 8.28 ± 2.10 mVs, respectively, group 2: 274.0 ± 75.0 mV and 6.82 ± 2.70 mVs respectively, P < 0.05). Magnitude and area under the wavelet curve for short frequency periods ranging from 60 to 220 minutes were also significantly higher in group 1 (P < 0.05).
The 24-hour IOP related fluctuations characteristics, as assessed by a CLS, may act as a risk factor for progression in OAG. In association with other predictive factors of glaucoma progression, the CLS may help adjust treatment strategy earlier.
本研究旨在比较两组开角型青光眼（OAG）患者的视野进展率的 24 小时眼压（IOP）相关波动监测。
在波尔多大学医院进行的横断面研究。使用接触镜传感器（CLS；Triggerfish；SENSIMED，Etagnières，瑞士）进行 24 小时监测。使用视野测试（Octopus；HAAG-STREIT，瑞士）的平均偏差（MD）参数的线性回归计算进展率。患者被分为两组：组 1 的 MD 进展率<-0.5dB/年，组 2 的 MD 进展率≥-0.5dB/年。开发了一种自动信号处理程序，并使用小波变换分析对监测信号进行频率滤波，以比较两组之间的输出信号。进行了多变量分类器以预测进展较快的组。
共纳入 54 例 54 只眼。组 1（n=22）的平均进展率为-1.09±0.60dB/年，组 2（n=32）为-0.12±0.13dB/年。组 1 的 24 小时幅度和监测曲线下绝对面积明显高于组 2（组 1：343.1±62.3 毫伏[mV]和 8.28±2.10 mV，分别为 274.0±75.0 mV 和 6.82±2.70 mV，P<0.05）。短时间范围内（60-220 分钟）的幅度和小波曲线下面积也明显高于组 1（P<0.05）。
CLS 评估的 24 小时 IOP 相关波动特征可能是 OAG 进展的危险因素。与青光眼进展的其他预测因素相结合，CLS 可能有助于更早地调整治疗策略。
