Ohno H, Doi S, Fukuhara S, Nishikori M, Uchino H, Fujii H
Jpn J Cancer Res. 1985 Jul;76(7):563-6.
A new human cell line named FL-18, carrying a 14;18 translocation [t(14;18)(q32;q21)], was established from a Japanese patient with follicular small cleaved cell lymphoma. The established FL-18 cells had monoclonal surface immunoglobulins (IgG-kappa) and were negative for Epstein-Barr virus nuclear antigens. The high-resolution banding technique indicated the breakpoints of chromosomes 14 and 18 involved in the characteristic 14;18 translocation to be at sub-bands 14q32.3 and 18q21.3, respectively. The FL-18 cell line should be useful for studying oncogenic events associated with 14;18 translocation and karyotype evolution.
从一名患有滤泡性小裂细胞淋巴瘤的日本患者身上建立了一种名为FL-18的新人类细胞系，该细胞系携带14;18易位[t(14;18)(q32;q21)]。所建立的FL-18细胞具有单克隆表面免疫球蛋白（IgG-κ），且爱泼斯坦-巴尔病毒核抗原呈阴性。高分辨率显带技术表明，参与特征性14;18易位的14号和18号染色体的断点分别位于亚带14q32.3和18q21.3。FL-18细胞系对于研究与14;18易位和核型进化相关的致癌事件应是有用的。
