Semba K, Nishizawa M, Miyajima N, Yoshida M C, Sukegawa J, Yamanashi Y, Sasaki M, Yamamoto T, Toyoshima K
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5459-63. doi: 10.1073/pnas.83.15.5459.
An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.
在人类6号染色体基因组中已鉴定出一个名为syn（人类基因命名法中的SYN）的src/yes相关新基因，并通过分子克隆对其进行了表征。cDNA克隆的核苷酸序列分析表明，c-syn基因可编码一种蛋白酪氨酸激酶，其一级结构与v-yes和人类c-src蛋白非常相似。在各种细胞类型中均观察到c-syn基因的一个2.8千碱基转录本，其大小与c-yes、c-src和c-fgr基因的转录本不同。这些结果表明，syn是酪氨酸激酶癌基因家族的一个新成员。
