Wu Liang, Wang Xiu-Ping, Zhu Yun-Xia, Tan Yan-Ping, Li Chun-Ming
Department of Dermatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Department of Dermatology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang 330000, Jiangxi Province, China.
World J Clin Cases. 2024 Sep 16;12(26):5850-5853. doi: 10.12998/wjcc.v12.i26.5850.
In this editorial, we comment on the article by Cao . Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry, the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus (GDM) to the healthy ones. GDM symptoms may involve abnormalities in inflammatory response, complement system, coagulation cascade activation, and lipid metabolism. Retinol binding protein 4 and angiopoietin like 8 are potential early indicators of GDM. GDM stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and stillbirth. Nevertheless, none of the biomarkers discovered so far have demonstrated effectiveness in predicting GDM. Our topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.
在这篇社论中，我们对曹的文章进行评论。通过应用相对和绝对定量等压标签技术结合液相色谱-串联质谱法，研究人员在比较妊娠期糖尿病（GDM）孕妇与健康孕妇的血清样本时，观察到47种蛋白质有显著差异表达。GDM症状可能涉及炎症反应、补体系统、凝血级联激活和脂质代谢异常。视黄醇结合蛋白4和血管生成素样蛋白8是GDM的潜在早期指标。GDM是孕期最常见的代谢并发症之一，与子痫前期和死产等严重母婴结局有关。然而，迄今为止发现的生物标志物均未显示出预测GDM的有效性。我们的主题旨在促进对蛋白质组学在GDM早期产前筛查应用方面进展的深入了解。
