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解读脓疱型坏疽性脓皮病的组织病理学：一种多学科诊断方法

Decoding the Histopathology of Pustular Pyoderma Gangrenosum: A Multidisciplinary Approach to Diagnosis.

作者信息

Bavikar Rupali, Singh Dipti

机构信息

Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.

出版信息

Cureus. 2024 Aug 17;16(8):e67059. doi: 10.7759/cureus.67059. eCollection 2024 Aug.

DOI:10.7759/cureus.67059
PMID:39286710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403648/
Abstract

This article discusses the rare neutrophilic dermatosis pustular pyoderma gangrenosum (PG), characterized by necrotizing skin lesions. It highlights the importance of thorough histological examination in diagnosing this variation, which resembles other pustular dermatoses. The case study of a 54-year-old female highlights the unique histological aspects of PG, including epidermal erosion, neutrophilic infiltration, sterile abscesses, and no vasculitis. The article emphasizes the need for differential diagnosis and clinical correlation, emphasizing the importance of collaboration between physicians and pathologists for accurate diagnosis.

摘要

本文讨论了罕见的嗜中性皮病——坏疽性脓皮病（PG），其特征为坏死性皮肤病变。文中强调了全面组织学检查在诊断这种与其他脓疱性皮肤病相似的变异型疾病中的重要性。一名54岁女性的病例研究突出了PG独特的组织学特征，包括表皮糜烂、嗜中性粒细胞浸润、无菌性脓肿且无血管炎。本文强调了鉴别诊断和临床关联的必要性，强调了医生与病理学家合作以进行准确诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/c08578f77929/cureus-0016-00000067059-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/771858f18556/cureus-0016-00000067059-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/c3034241a878/cureus-0016-00000067059-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/ec38bbf15e2e/cureus-0016-00000067059-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/5a528a528fdb/cureus-0016-00000067059-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/c08578f77929/cureus-0016-00000067059-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/771858f18556/cureus-0016-00000067059-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/c3034241a878/cureus-0016-00000067059-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/ec38bbf15e2e/cureus-0016-00000067059-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/5a528a528fdb/cureus-0016-00000067059-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ac1/11403648/c08578f77929/cureus-0016-00000067059-i05.jpg

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本文引用的文献

1
Clinical guidance of pyoderma gangrenosum 2022.2022年坏疽性脓皮病临床指南
J Dermatol. 2023 Sep;50(9):e253-e275. doi: 10.1111/1346-8138.16845. Epub 2023 Jun 13.
2
Pyoderma gangrenosum.坏疽性脓皮病。
Nat Rev Dis Primers. 2020 Oct 8;6(1):81. doi: 10.1038/s41572-020-0213-x.
3
Clinical and histological patterns and treatment of pyoderma gangrenosum.坏疽性脓皮病的临床、组织学表现及治疗
Pan Afr Med J. 2020 Jun 2;36:59. doi: 10.11604/pamj.2020.36.59.12329. eCollection 2020.
4
Giant pyoderma gangrenosum in a patient with ulcerative colitis: A case report.一名溃疡性结肠炎患者的巨大坏疽性脓皮病：病例报告。
Medicine (Baltimore). 2020 Feb;99(6):e18795. doi: 10.1097/MD.0000000000018795.
5
Pyoderma gangrenosum - a guide to diagnosis and management .坏疽性脓皮病—诊断与治疗指南
Clin Med (Lond). 2019 May;19(3):224-228. doi: 10.7861/clinmedicine.19-3-224.
6
Neutrophilic dermatoses: a broad spectrum of disease.嗜中性皮病：一系列广泛的疾病。
G Ital Dermatol Venereol. 2018 Apr;153(2):265-272. doi: 10.23736/S0392-0488.18.05841-8. Epub 2018 Jan 24.
7
Pustular pyoderma gangrenosum: an uncommon variant which is easily misdiagnosed.脓疱型坏疽性脓皮病：一种易被误诊的罕见变异型。
Dermatol Online J. 2008 Feb 28;14(2):21.
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Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria.坏疽性脓皮病：临床病理相关性及拟诊标准
Int J Dermatol. 2004 Nov;43(11):790-800. doi: 10.1111/j.1365-4632.2004.02128.x.
9
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