J Clin Invest. 2024 Sep 17;134(18):e183115. doi: 10.1172/JCI183115.
Fibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation. ADAMTS12 facilitates proteolysis by cleaving various substrates such as ECM components, which are vital for cellular signaling and remodeling. Additionally, it modulates cell-matrix interactions, influencing cell adhesion and migration, and plays an important role in the inflammatory processes. Understanding the role of ADAMTS12 offers potential therapeutic insights for targeting fibrosis in progressive diseases.
纤维化是大多数进行性和退行性疾病的常见表现，成纤维细胞激活和基质积累起着关键作用。在本期 JCI 中， Hoeft 等人确定了 ADAMTS12 在成纤维细胞激活中的重要作用。ADAMTS12 是一种分泌蛋白，参与细胞外基质 (ECM) 的重塑、细胞信号转导和炎症。ADAMTS12 通过切割各种底物（如 ECM 成分）促进蛋白水解，这些底物对于细胞信号转导和重塑至关重要。此外，它还调节细胞-基质相互作用，影响细胞黏附和迁移，并在炎症过程中发挥重要作用。了解 ADAMTS12 的作用为靶向进行性疾病中的纤维化提供了潜在的治疗思路。
