原发性震颤的新视角：[具体物种]和[具体物种]属的潜在病因学作用

A new perspective on essential tremor: the potential etiologic role of and spp.

作者信息

Celik Tuncay, Altunisik Erman, Yar Turkan Mutlu, Gul Tuba, Kasko Arici Yeliz, Karaman Ulku

机构信息

Faculty of Medicine, Department of Microbiology, Adiyaman University, Adiyaman, Turkey.

Faculty of Medicine, Department of Neurology, Adiyaman University, Adiyaman, Turkey.

出版信息

Int J Environ Health Res. 2024 Sep 17:1-8. doi: 10.1080/09603123.2024.2404480.

DOI:10.1080/09603123.2024.2404480

PMID:39287148

Abstract

Our aim was to examine the relationship between () and infection and patients with essential tremor (ET). This study comprised a total of 174 participants, consisting of 99 patients with ET and 75 healthy controls. The presence of anti- IgG and anti- IgG antibodies was investigated using ELISA. The relationship between the severity of the disease and the seropositivity of and were examined. The seropositivity rate for anti- IgG antibodies among patients and control groups were 43.4% and 12%, respectively (odds ratio [OR]: 5.63; 95% CI: 2.53-12.56). The patient group exhibited a higher seroprevalence of anti- IgG antibodies (32.3%) compared with the control group (13.3%; OR: 3.10; 95% CI: 1.41-6.83; = 0.004). This study suggests that and infections can contribute to the pathogenic mechanisms underlying ET and could be risk factors for ET.

摘要

我们的目的是研究（）与感染以及特发性震颤（ET）患者之间的关系。本研究共纳入174名参与者，其中包括99例ET患者和75名健康对照者。采用酶联免疫吸附测定（ELISA）检测抗IgG和抗IgG抗体的存在情况。研究了疾病严重程度与和的血清阳性率之间的关系。患者组和对照组中抗IgG抗体的血清阳性率分别为43.4%和12%（优势比[OR]：5.63；95%置信区间[CI]：2.53 - 12.56）。与对照组（13.3%；OR：3.10；95% CI：1.41 - 6.83；P = 0.004）相比，患者组抗IgG抗体的血清阳性率更高（32.3%）。本研究表明，和感染可能参与了ET的发病机制，可能是ET的危险因素。