Simek I-M, Sturdza A, Knoth J, Spannbauer A, Bergler-Klein J, Vögele-Kadletz M, Widder J, Schmid M P
Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, General Hospital of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Department of Cardiology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria.
Strahlenther Onkol. 2025 Jan;201(1):71-81. doi: 10.1007/s00066-024-02274-y. Epub 2024 Sep 17.
Cardiac metastasis from cervical cancer is rare and only scarcely documented. We aim to present a new case and systematically summarize the available literature.
PubMed, Scopus, Web of Science, Central, and ClinicalTrials.gov were systematically searched following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Results were screened via title, abstract, and full text. Additionally, the reference lists of all papers chosen for the review were screened.
Eighty-one papers were identified, describing 86 cases in total. Cardiac metastasis occurred at all stages of cervical cancer and in all age groups. Median time from initial diagnosis to diagnosis of cardiac metastasis was 12 months. Patients mainly complained of dyspnea and chest pain, 60.8% had pathologic ECG (electrocardiographic) findings. The cardiac mass was most frequently detected by transthoracic echography. The most common tumor histology was squamous cell carcinoma. Chemotherapy and surgical interventions were the main treatment modalities. Median survival after diagnosis of cardiac metastasis was 3 months.
This largest review on cardiac metastases from cervical cancer confirmed the heart as a very infrequent site of metastasis. There are < 100 cases described in the literature, with very poor prognosis and undefined clinical management.
宫颈癌的心脏转移罕见，仅有极少的文献记载。我们旨在呈现一例新病例并系统总结现有文献。
按照PRISMA（系统评价和Meta分析的首选报告项目）标准，对PubMed、Scopus、科学网、CENTRAL和ClinicalTrials.gov进行系统检索。通过标题、摘要和全文对结果进行筛选。此外，还对纳入综述的所有论文的参考文献列表进行了筛选。
共识别出81篇论文，总计描述了86例病例。宫颈癌各阶段及各年龄组均有发生心脏转移的情况。从初次诊断到诊断出心脏转移的中位时间为12个月。患者主要主诉为呼吸困难和胸痛，60.8%有心电图病理性表现。经胸超声心动图最常检测到心脏肿物。最常见的肿瘤组织学类型为鳞状细胞癌。化疗和手术干预是主要治疗方式。诊断出心脏转移后的中位生存期为3个月。
这项关于宫颈癌心脏转移的最大规模综述证实，心脏是非常罕见的转移部位。文献中描述的病例不足100例，预后极差且临床管理尚不明确。
