LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Adv Exp Med Biol. 2024;1460:883-918. doi: 10.1007/978-3-031-63657-8_30.
Obesity represents a global health concern, affecting individuals of all age groups across the world. The prevalence of excess weight and obesity has escalated to pandemic proportions, leading to a substantial increase in the incidence of various comorbidities, such as cardiovascular diseases, type 2 diabetes, and cancer. This chapter seeks to provide a comprehensive exploration of the pathways through which endocrine-disrupting chemicals can influence the pathophysiology of obesity. These mechanisms encompass aspects such as the regulation of food intake and appetite, intestinal fat absorption, lipid metabolism, and the modulation of inflammation. This knowledge may help to elucidate the role of exogenous molecules in both the aetiology and progression of obesity.
肥胖是一个全球性的健康问题，影响着世界各地各个年龄段的人。超重和肥胖的流行已经达到了大流行的程度，导致各种合并症的发病率显著增加，如心血管疾病、2 型糖尿病和癌症。本章旨在全面探讨内分泌干扰物如何影响肥胖的病理生理学途径。这些机制包括调节食物摄入和食欲、肠道脂肪吸收、脂代谢和炎症调节等方面。这些知识可能有助于阐明外源性分子在肥胖的病因和进展中的作用。
