Yun-Choi H S, Kim S O, Kim J H, Lee J R, Cho H I
J Nat Prod. 1985 May-Jun;48(3):363-70. doi: 10.1021/np50039a003.
The smear method developed by Velaskar and Chitre was modified to allow the massive screening of plant extracts and/or fractions for platelet antiaggregating activity. Aspirin and papaverine, known inhibitors of platelet aggregation, were tested by the modified method and showed comparable results with previously reported data. Fifty-four fractions prepared from eighteen plant species were screened for their inhibitory effects on adenosine 5'-diphosphate, arachidonic acid, or collagen-induced rat platelet aggregation. The results suggest that plants could be a potential source of inhibitors of platelet aggregation.
维拉斯卡尔和奇特雷开发的涂片法经过改良，以实现对植物提取物和/或馏分进行大规模血小板抗聚集活性筛选。已知的血小板聚集抑制剂阿司匹林和罂粟碱通过改良方法进行了测试，结果与先前报道的数据相当。对从18种植物中制备的54个馏分进行了筛选，以考察它们对二磷酸腺苷、花生四烯酸或胶原诱导的大鼠血小板聚集的抑制作用。结果表明，植物可能是血小板聚集抑制剂的潜在来源。
