School of Public Health, Sun Yat-sen University, Guangzhou, China.
Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2400750. doi: 10.1080/21645515.2024.2400750. Epub 2024 Sep 17.
The HPV vaccine, which has been demonstrated to be an effective method of reducing the risk of developing cervical cancer, is still being underutilized among college students in China. To assess the current status of HPV vaccine hesitancy among college students in Guangdong Province after the COVID-19 outbreak, and to systematically analyze the influencing factors of HPV vaccine hesitancy and construct a prediction model based on the WHO 3Cs model. A cross-sectional web-based survey was conducted in June 2023 among female college students in four cities in Guangdong Province. The data were analyzed using binary logistic regression with a focus on the 3Cs model: Complacency, Convenience, and Confidence. LASSO regression was employed to analyze the variables deemed to be of significance and to construct predictive models. Out of 1399 participants, 86.5% expressed no hesitancy toward HPV vaccination. However, 11.9% exhibited hesitancy, and 1.6% refused vaccination altogether. Factors such as trust in vaccine efficacy, perception of HPV infection risk, price considerations, and constraints like distance or time were significant contributors to hesitancy. Knowledge of the HPV vaccine, socio-demographic characteristics, and the educational level of participants' mothers also played a role in vaccine hesitancy. It is recommended that targeted interventions be implemented within educational institutions with the aim of raising awareness of cervical cancer and HPV vaccines, simplifying the scheduling of vaccination appointments, and increasing affordability through the implementation of strategic purchasing measures or subsidy schemes.
HPV 疫苗已被证明是降低宫颈癌发病风险的有效方法，但在中国大学生中的使用率仍然较低。本研究旨在评估 COVID-19 疫情后广东省大学生 HPV 疫苗犹豫现状，并基于世卫组织 3C 模式系统分析 HPV 疫苗犹豫的影响因素，构建预测模型。本研究于 2023 年 6 月采用整群抽样方法，选取广东省 4 个城市的在校女大学生进行 HPV 疫苗犹豫的横断面调查。采用二分类 Logistic 回归分析重点关注 3C 模式（自满、便利和信心）的影响因素。采用 LASSO 回归分析筛选有意义的变量，并构建预测模型。共纳入 1399 名大学生，86.5%表示对 HPV 疫苗无犹豫，11.9%表示犹豫，1.6%表示拒绝接种。对疫苗效力的信任、HPV 感染风险的认知、价格考虑以及距离或时间等因素是犹豫的重要原因。对 HPV 疫苗的了解、社会人口学特征以及母亲的教育程度也是 HPV 疫苗犹豫的影响因素。建议在教育机构中实施有针对性的干预措施，旨在提高对宫颈癌和 HPV 疫苗的认识，简化疫苗接种预约，并通过实施战略采购措施或补贴计划来提高可负担性。
