van der Kolk Birgitta W, Pirinen Eija, Nicoll Rachel, Pietiläinen Kirsi H, Heinonen Sini
Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Finland; Faculty of Medicine, Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
Trends Endocrinol Metab. 2025 Apr;36(4):339-363. doi: 10.1016/j.tem.2024.08.002. Epub 2024 Sep 16.
Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain these improvements over time. Adipose tissue and skeletal muscle metabolism are crucial in weight regulation, and obesity is linked to mitochondrial dysfunction in both tissues. The impact of bariatric surgery versus dieting on adipose tissue and skeletal muscle mitochondrial metabolism remains to be elucidated. Understanding the molecular pathways that modulate tissue metabolism following weight loss holds potential for identifying novel therapeutic targets in obesity management. This narrative review summarizes current knowledge on mitochondrial metabolism following bariatric surgery and diet-induced weight loss in adipose tissue and skeletal muscle, and sheds light on their respective effects.
肥胖是一个全球性的重大健康问题，伴有各种代谢并发症。减肥手术和节食都能实现体重减轻并改善全身代谢，但随着时间推移，它们维持这些改善效果的能力有所不同。脂肪组织和骨骼肌代谢在体重调节中至关重要，而肥胖与这两种组织中的线粒体功能障碍有关。减肥手术与节食对脂肪组织和骨骼肌线粒体代谢的影响仍有待阐明。了解体重减轻后调节组织代谢的分子途径，有望为肥胖管理确定新的治疗靶点。这篇叙述性综述总结了减肥手术和节食诱导体重减轻后，脂肪组织和骨骼肌中线粒体代谢的现有知识，并阐明了它们各自的作用。
