Ge Xiaochuan, Wang Zhe, Song Yafeng, Meng Hua
Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Key Laboratory of Sports and Physical Fitness of the Ministry of Education, Beijing Sport University, Beijing, China.
Front Endocrinol (Lausanne). 2024 Nov 25;15:1488715. doi: 10.3389/fendo.2024.1488715. eCollection 2024.
In the context of obesity epidemic as a major global public health challenge, bariatric surgery stands out for its significant and long-lasting effectiveness in addressing severe obesity and its associated comorbidities. Skeletal muscle mitochondrial function, which is crucial for maintaining metabolic health, tends to deteriorate with obesity. This review summarized current evidence on the effects of bariatric surgery on skeletal muscle mitochondrial function, with a focus on mitochondrial content, mitochondrial dynamics, mitochondrial respiration and mitochondrial markers in glucolipid metabolism. In conclusion, bariatric surgery impacts skeletal muscle through pathways related to mitochondrial function and induces mitochondrial remodeling in skeletal muscle in various aspects. Future studies should focus on standardized methodologies, larger sample sizes, and better control of confounding factors to further clarify the role of mitochondrial remodeling in the therapeutic benefits of bariatric surgery.
在肥胖流行成为一项重大全球公共卫生挑战的背景下，减肥手术因其在治疗重度肥胖及其相关合并症方面具有显著且持久的效果而备受瞩目。骨骼肌线粒体功能对于维持代谢健康至关重要，但往往会随着肥胖而恶化。本综述总结了目前关于减肥手术对骨骼肌线粒体功能影响的证据，重点关注线粒体含量、线粒体动力学、线粒体呼吸以及糖脂代谢中的线粒体标志物。总之，减肥手术通过与线粒体功能相关的途径影响骨骼肌，并在多个方面诱导骨骼肌中的线粒体重塑。未来的研究应聚焦于标准化方法、更大样本量以及更好地控制混杂因素，以进一步阐明线粒体重塑在减肥手术治疗益处中的作用。
