Majeno Angelina, Granger Douglas A, Bryce Crystal I, Riis Jenna L
Department of Psychological Science, 4201 Social and Behavioral Sciences Gateway, University of California Irvine, Irvine, CA, 92697-7085, USA.
Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, CA, USA.
Int J Behav Med. 2024 Sep 17. doi: 10.1007/s12529-024-10322-1.
Understanding the biological processes underlying poor self-rated health (SRH) can inform prevention efforts. The COVID-19 pandemic highlighted the importance of using self-reported measures and self-collected biospecimens, such as saliva, to understand physiological functioning and assist with health surveillance and promotion. However, the associations between salivary analytes and SRH remain understudied. The current study addresses this gap.
In a laboratory-based study, 99 healthy adults (M = 23.8 years, SD = 4.5, 55% men, 43% non-Hispanic White) reported their SRH and provided saliva and blood samples that were assayed for adiponectin, C-reactive protein (CRP), uric acid (UA), and cytokines (IL-1β, IL-6, IL-8, TNF-α). Principal component analyses assessed the component loadings and generated factor scores for saliva and serum analytes. Binary logistic regressions examined the associations between these components and poor SRH.
Salivary analytes loaded onto two components (component 1: adiponectin and cytokines; component 2: CRP and UA) explaining 58% of the variance. Serum analytes grouped onto three components (component 1: IL-8 and TNF-α; component 2: CRP, IL-1β, and IL-6; component 3: adiponectin and UA) explaining 76% of the variance. Higher salivary component 1 scores predicted higher odds of reporting poor SRH (OR 1.53, 95%CI [1.10, 2.11]). Higher serum component 2 scores predicted higher odds of reporting poor SRH (OR 2.37, 95%CI [1.20, 4.67]). When examined in the same model, salivary component 1 (OR 1.79, 95%CI [1.17, 2.75]) and serum component 2 were associated with poorer SRH (OR 7.74, 95%CI [2.18, 27.40]).
In our sample, whether measured in saliva or serum, indices of inflammatory processes were associated with SRH.
了解自评健康状况不佳（SRH）背后的生物学过程可为预防工作提供信息。2019冠状病毒病（COVID-19）大流行凸显了使用自我报告措施和自我采集的生物样本（如唾液）来了解生理功能并协助健康监测和促进的重要性。然而，唾液分析物与SRH之间的关联仍未得到充分研究。本研究填补了这一空白。
在一项基于实验室的研究中，99名健康成年人（平均年龄M = 23.8岁，标准差SD = 4.5，55%为男性，43%为非西班牙裔白人）报告了他们的SRH，并提供了唾液和血液样本，用于检测脂联素、C反应蛋白（CRP）、尿酸（UA）和细胞因子（IL-1β、IL-6、IL-8、TNF-α）。主成分分析评估了成分载荷，并生成了唾液和血清分析物的因子得分。二元逻辑回归分析了这些成分与SRH不佳之间的关联。
唾液分析物分为两个成分（成分1：脂联素和细胞因子；成分2：CRP和UA），解释了58%的方差。血清分析物分为三个成分（成分1：IL-8和TNF-α；成分2：CRP、IL-1β和IL-6；成分3：脂联素和UA），解释了76%的方差。唾液成分1得分越高，报告SRH不佳的几率越高（比值比OR = 1.53，95%置信区间CI [1.10, 2.11]）。血清成分2得分越高，报告SRH不佳的几率越高（OR = 2.37，95%CI [1.20, 4.67]）。在同一模型中进行检验时，唾液成分1（OR = 1.79，95%CI [1.17, 2.75]）和血清成分2与较差的SRH相关（OR = 7.74，95%CI [2.18, 27.40]）。
在我们的样本中，无论在唾液还是血清中测量，炎症过程指标都与SRH相关。
