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中国健康受试者与高加索健康受试者之间的角膜生物力学差异

Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects.

作者信息

Vinciguerra Riccardo, Herber Robert, Wang Yan, Zhang Fengju, Zhou Xingtao, Bai Ji, Yu Keming, Chen Shihao, Fang Xuejun, Raiskup Frederik, Vinciguerra Paolo

机构信息

Humanitas San Pio X Hospital, Milan, Italy.

Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany.

出版信息

Front Med (Lausanne). 2022 Feb 25;9:834663. doi: 10.3389/fmed.2022.834663. eCollection 2022.

DOI:10.3389/fmed.2022.834663
PMID:35280913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8914014/
Abstract

PURPOSE

The aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs).

METHODS

Two thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm. The DCRs assessed were Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R), deformation amplitude ratio (DAratio), stiffness parameter at applanation 1 (SPA1), ARTh (Ambrósio's Relational Thickness to the horizontal profile), and the novel Stress Strain Index (SSI).

RESULTS

After age-, CCT-, and IOP- matching, 503 Chinese were assigned to 452 Caucasians participants. Statistical analysis showed a statistical significant difference between Chinese and Caucasian Healthy subjects in the values of SPA1 ( = 0.008), Arth ( = 0.008), and SSI ( < 0.001). Conversely, DA, A1v, DAratio, and 1/R were not significantly different between the two ethnical groups ( > 0.05).

CONCLUSION

We found significant differences in the values of the DCRs provided by the Corvis ST between Chinese and Caucasian healthy subjects.

摘要

目的

本研究旨在评估白种人和中国健康受试者在Corvis ST动态角膜反应参数（DCRs）方面的差异。

方法

本多中心回顾性研究纳入了2889名健康的白种人和中国受试者。随后，使用病例对照匹配算法，根据年龄、眼压（IOP）和角膜厚度（CCT）将中国受试者与白种人进行匹配。评估的DCRs包括压平1时的变形幅度（DA）、压平1速度（A1v）、综合半径（1/R）、变形幅度比（DAratio）、压平1时的刚度参数（SPA1）、ARTh（水平轮廓的安布罗西奥关系厚度）和新的应力应变指数（SSI）。

结果

在年龄、CCT和IOP匹配后，503名中国受试者被分配到452名白种人参与者中。统计分析显示，中国和白种人健康受试者在SPA1值（P = 0.008）、Arth（P = 0.008）和SSI（P < 0.001）方面存在统计学显著差异。相反，两组在DA、A1v、DAratio和1/R方面无显著差异（P > 0.05）。

结论

我们发现中国和白种人健康受试者在Corvis ST提供的DCRs值方面存在显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/c46bc597b24d/fmed-09-834663-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/412d5d51aba8/fmed-09-834663-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/53318fe6f50f/fmed-09-834663-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/c46bc597b24d/fmed-09-834663-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/412d5d51aba8/fmed-09-834663-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/53318fe6f50f/fmed-09-834663-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfa/8914014/c46bc597b24d/fmed-09-834663-g0003.jpg

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