Wang Wei, He Miao, He Hong, Zhang Chi, Jin He, Zhong Xingwu
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Haikou, Hainan Province, China.
Cont Lens Anterior Eye. 2017 Apr;40(2):97-103. doi: 10.1016/j.clae.2016.12.003. Epub 2016 Dec 10.
To evaluate the corneal biomechanical metrics by Corvis ST (CST) in healthy Chinese adults.
This cross-sectional study used CST to measure intraocular pressure (IOP), central corneal thickness (CCT), and corneal biomechanical parameters, including time, velocity, length, deformation amplitude at the first (A1T, A1V, A1L, A1DA) and second applanation (A2T, A2V, A2L, A2DA), time, radius curvature and deformation amplitude at highest concavity (HCT, HCR, HCDA) and peak distance (PD).
A total of 158 healthy adults (158 eyes) were included in the final analysis. No significant differences were observed between male and female for any biomechanical parameters (All P>0.05). With increasing age, a significant trend of increase was detected among A1V, A1DA, A2T, A2DA, and HCDA (All P<0.05). The A1T decreased significantly with increasing age (P<0.001). The cluster analysis using Pearson coefficient divided the CST parameters into 5 sub-clusters, where IOP, A1T, A2V had strongest relation. The multivariable linear regression analyses demonstrated that age was independently associated with A1DA, A2DA, and HCDA. The IOP was positively associated with A1T, A2V, and HCR, while negatively with A1V, A2T, HCT, PD, and HCDA. The CCT was positively correlated with A1L, A1DA, A2L, A2V, or HCR.
CST provided informative corneal biomechanical measurements in this Chinese population. Most corneal biomechanical parameters were associated with IOP, and several parameters were influenced by age or CCT, suggesting adjustment of these factors was needed before interpretations of CST outputs.
通过Corvis ST（CST）评估健康中国成年人的角膜生物力学指标。
本横断面研究采用CST测量眼压（IOP）、中央角膜厚度（CCT）和角膜生物力学参数，包括时间、速度、长度、第一次压平（A1T、A1V、A1L、A1DA）和第二次压平（A2T、A2V、A2L、A2DA）时的变形幅度、最高凹陷处的时间、曲率半径和变形幅度（HCT、HCR、HCDA）以及峰值距离（PD）。
最终分析纳入了158名健康成年人（158只眼）。在任何生物力学参数方面，男性和女性之间均未观察到显著差异（所有P>0.05）。随着年龄的增长，在A1V、A1DA、A2T、A2DA和HCDA中检测到显著的增加趋势（所有P<0.05）。A1T随着年龄的增长显著降低（P<0.001）。使用Pearson系数的聚类分析将CST参数分为5个子聚类，其中IOP、A1T、A2V具有最强的相关性。多变量线性回归分析表明，年龄与A1DA、A2DA和HCDA独立相关。IOP与A1T、A2V和HCR呈正相关，而与A1V、A2T、HCT、PD和HCDA呈负相关。CCT与A1L、A1DA、A2L、A2V或HCR呈正相关。
CST为该中国人群提供了丰富的角膜生物力学测量信息。大多数角膜生物力学参数与IOP相关，并且一些参数受年龄或CCT的影响，这表明在解释CST输出结果之前需要对这些因素进行调整。
