Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77 Sakju-ro, Chuncheon-si, Gangwon-do, 24253, Republic of Korea.
Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Ann Clin Transl Neurol. 2024 Oct;11(10):2799-2804. doi: 10.1002/acn3.52175. Epub 2024 Sep 17.
A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi-omics data (N = 702). Among 44 candidate miRNAs, miR-133b was significantly associated with AD and Braak positivity. Higher miR-133b expression was also associated with higher NPTX2 gene expression and better cognition. Mediation analysis showed that miR-133b partially influences AD and cognition through the NPTX2 protein. Our integrated approach suggests a potential role of miR-133b in synaptic integrity and offers new insights into AD pathogenesis.
一种突触蛋白，神经元五聚素 2（NPTX2），已成为阿尔茨海默病（AD）的关键生物标志物。我们鉴定了针对 NPTX2 的候选 miRNA，并使用多组学数据（N=702）进行了关联和中介分析。在 44 种候选 miRNA 中，miR-133b 与 AD 和 Braak 阳性显著相关。较高的 miR-133b 表达也与更高的 NPTX2 基因表达和更好的认知相关。中介分析表明，miR-133b 通过 NPTX2 蛋白部分影响 AD 和认知。我们的综合方法表明 miR-133b 在突触完整性中可能发挥作用，并为 AD 的发病机制提供了新的见解。
