School of Medicine, CHA University, Pocheon-si, Gyeonggi-do, 11160, South Korea.
Department of Life Science and Biotechnology (LSBT), Underwood Division (UD), Underwood International College, Yonsei University, Seoul-si, 03722, South Korea.
J Mater Chem B. 2024 Oct 23;12(41):10446-10465. doi: 10.1039/d4tb01362j.
Chitosan bio-adhesives bond strongly with various biological tissues, such as skin, mucosa, and internal organs. Their adhesive ability arises from amino acid and hydroxyl groups in chitosan, facilitating interactions with tissue surfaces through chemical (ionic, covalent, and hydrogen) and physical (chain entanglement) bonding. As non-toxic, biodegradable, and biocompatible materials, chitosan bio-adhesives are a safe option for medical therapies. They are particularly suitable for drug delivery, wound healing, and tissue regeneration. In this review, we address chitosan-based bio-adhesives and the mechanisms associated with them. We also discuss different chitosan composite-based bio-adhesives and their biomedical applications in wound healing, drug delivery, hemostasis, and tissue regeneration. Finally, challenges and future perspectives for the clinical use of chitosan-based bio-adhesives are discussed.
壳聚糖生物粘合剂与各种生物组织（如皮肤、黏膜和内脏器官）具有很强的结合能力。它们的粘合能力来自壳聚糖中的氨基酸和羟基，通过化学（离子、共价和氢键）和物理（链缠结）键合促进与组织表面的相互作用。作为无毒、可生物降解和生物相容的材料，壳聚糖生物粘合剂是一种安全的医疗治疗选择。它们特别适用于药物输送、伤口愈合和组织再生。在本综述中，我们将介绍基于壳聚糖的生物粘合剂及其相关机制。我们还讨论了不同的壳聚糖复合基生物粘合剂及其在伤口愈合、药物输送、止血和组织再生方面的生物医学应用。最后，讨论了壳聚糖基生物粘合剂临床应用的挑战和未来展望。
