Vrabec Tina L, Kilgore Kevin L, Wainright Jesse S, Bhadra Niloy
Case Western Reserve University 10900 Euclid Ave., Cleveland, Ohio.
Case Western Reserve University 10900 Euclid Ave., Cleveland, Ohio 44106.
Int IEEE EMBS Conf Neural Eng. 2019 Mar;2019:356-359. doi: 10.1109/ner.2019.8716928. Epub 2019 May 20.
Direct current (DC) can be applied to a nerve to generate a complete nerve block. However, using conventional platinum electrodes, reactions occur at the nerve interface causing damage to the nerve. The electrode can be separated from the nerve using a biocompatible, ionically conducting medium, which isolates the damaging reactions in a vessel away from the nerve. This electrode has previously been referred to as the Separated Interface Nerve Electrode (SINE). Recent experiments have shown that when a complete block is applied, for a prolonged period of time, there is a delay in the recovery of the response. For many applications it would be advantageous to have instantaneous recovery. To achieve this, the SINE electrode was used to provide a complete, instantaneous nerve block at the block threshold for 10 minutes and then the current was reversed for selected time periods to determine if instantaneous recovery could be achieved. Depending on the length of time of the repolarization, the amount of time for recovery can be reduced by as much as 50%.
直流电（DC）可施加于神经以产生完全性神经阻滞。然而，使用传统的铂电极时，在神经界面会发生反应，从而对神经造成损伤。可使用生物相容性的离子传导介质将电极与神经隔开，该介质可将损伤反应隔离在远离神经的容器中。这种电极以前被称为分离界面神经电极（SINE）。最近的实验表明，当长时间施加完全性阻滞时，反应恢复存在延迟。对于许多应用而言，实现即时恢复将是有利的。为了实现这一点，使用SINE电极在阻滞阈值下提供10分钟的完全性即时神经阻滞，然后在选定的时间段内反转电流，以确定是否可以实现即时恢复。根据复极化的时间长度，恢复时间可减少多达50%。
