Al-Housni Obyda, Alonso Jessica M, Thornburg Matthew, Cancio Enny
HCA Florida Kendall Hospital, Miami, FL.
Dr Kiran C Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL.
HCA Healthc J Med. 2024 Aug 1;5(4):449-452. doi: 10.36518/2689-0216.1650. eCollection 2024.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disease whose acronymic name stands for the symptoms commonly seen in the disease. These symptoms typically occur simultaneously, in different combinations, in patients during exacerbations of the disease. SAPHO syndrome is a rare disease, most frequently seen in patients aged 30 to 50. It is estimated to be found in 1 in 10 000 persons in White populations, with an even lower incidence seen in non-White populations.
A post-menopausal woman with a medical history of SAPHO presented to the emergency department with left foot pain and chest pain with palpitation. She had chronic pustular rashes, located on the bilateral soles of the feet, bilateral palms, neck, and abdomen, which she stated appeared hours after the initial presentation of her pain. Chest X-ray readings showed osteitis and sclerosis of the sternocostoclavicular joint and first rib, a radiological finding of SAPHO syndrome. The patient was successfully treated with nonsteroidal anti-inflammatory drugs for pain relief and IV corticosteroids for the rheumatoid-like inflammatory aspect of SAPHO.
While SAPHO syndrome is a rare disease, it is important to be aware of its manifestations and symptoms, such as the patient's rash, foot and chest pain, in addition to the dermatological symptoms appearing simultaneously. An early diagnosis can provide patients with accurate and appropriate treatment.
滑膜炎、痤疮、脓疱病、骨质增生和骨炎（SAPHO）综合征是一种自身炎症性疾病，其首字母缩写代表了该疾病中常见的症状。这些症状通常在疾病发作期间以不同组合同时出现在患者身上。SAPHO综合征是一种罕见疾病，最常见于30至50岁的患者。据估计，白种人中每10000人中有1人患病，非白种人的发病率更低。
一名有SAPHO病史的绝经后女性因左脚疼痛、胸痛伴心悸到急诊科就诊。她有慢性脓疱疹，位于双侧脚底、双侧手掌、颈部和腹部，她说这些皮疹在最初出现疼痛数小时后出现。胸部X线检查显示胸锁关节和第一肋骨有骨炎和硬化，这是SAPHO综合征的影像学表现。患者通过使用非甾体抗炎药缓解疼痛，并使用静脉注射皮质类固醇治疗SAPHO类似类风湿的炎症方面，得到了成功治疗。
虽然SAPHO综合征是一种罕见疾病，但了解其表现和症状很重要，例如患者的皮疹、足部和胸部疼痛，以及同时出现的皮肤症状。早期诊断可为患者提供准确和适当的治疗。
