Maboni Grazieli, Che Sunoh, Tallmadge Rebecca, De Luca Eliana, Goodman Laura B, Weese J Scott, Sanchez Susan
Athens Veterinary Diagnostic Laboratory, Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Department of Animal and Avian Sciences, University of Maryland, College Park, MD, United States.
Front Microbiol. 2024 Sep 3;15:1455453. doi: 10.3389/fmicb.2024.1455453. eCollection 2024.
Feline respiratory disease complex (FRDC) is a highly prevalent syndrome in cats that often result in fatal outcomes. FRDC etiology is complex, and often, multiple viral and bacterial pathogens are simultaneously associated with disease causation. There is limited information about the role of co-infections in pathogenesis and the current prevalence of pathogens in North America. We aimed to conduct a study using technical advances in molecular diagnosis and statistical modeling analysis to elucidate the occurrence of pathogens and how co-infections affect disease severity. We attained information from three diagnostic laboratories in North America regarding the occurrence of , , , 1 (FeHV-1), feline calicivirus (FCV), and influenza A, along with age, seasonality, sex, and clinical signs. We also evaluated the role of co-infections in disease severity. These pathogens were also investigated in clinically normal cats (control). The most detected pathogens were , FCV, and FeHV-1. Most pathogens were detected in the control group, highlighting the challenge of interpreting positive testing results. Co-infections of and FCV, as well as and FeHV-1, were important predictors of disease severity. Age, sex, and season had a minor impact on pathogen occurrence. This study provides new insights into FRDC and underlines the relevance of diagnostic panels to screen for a range of pathogens, providing knowledge for timely diagnosis and therapeutic interventions.
猫呼吸道疾病综合征（FRDC）是猫中一种高度流行的综合征，常导致致命后果。FRDC的病因复杂，通常多种病毒和细菌病原体同时与疾病发生有关。关于合并感染在发病机制中的作用以及北美病原体的当前流行情况，信息有限。我们旨在利用分子诊断和统计建模分析方面的技术进步进行一项研究，以阐明病原体的发生情况以及合并感染如何影响疾病严重程度。我们从北美的三个诊断实验室获取了有关[此处原文缺失具体病原体名称]、猫疱疹病毒1型（FeHV-1）、猫杯状病毒（FCV）和甲型流感的发生情况，以及年龄、季节性、性别和临床症状等信息。我们还评估了合并感染在疾病严重程度中的作用。在临床正常的猫（对照组）中也对这些病原体进行了调查。检测到最多的病原体是[此处原文缺失具体病原体名称]、FCV和FeHV-1。在对照组中检测到了大多数病原体，这凸显了解释阳性检测结果的挑战。[此处原文缺失具体病原体名称]与FCV以及[此处原文缺失具体病原体名称]与FeHV-1的合并感染是疾病严重程度的重要预测指标。年龄、性别和季节对病原体的发生影响较小。这项研究为FRDC提供了新的见解，并强调了诊断组合对筛查一系列病原体的相关性，为及时诊断和治疗干预提供了知识。
