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阿特珠单抗诱发的线性免疫球蛋白A大疱性皮肤病

Linear immunoglobulin A bullous dermatosis induced by atezolizumab.

作者信息

Almutairi Seba, Alessa Dana

机构信息

Division of Dermatology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

出版信息

Dermatol Reports. 2024 Feb 8;16(3):9923. doi: 10.4081/dr.2024.9923. eCollection 2024 Sep 2.

DOI:10.4081/dr.2024.9923
PMID:39290558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404540/
Abstract

Linear immunoglobulin A bullous dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that is reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody that targets programmed cell death ligand-1 and has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.

摘要

线状免疫球蛋白A大疱性皮肤病(LABD)是一种罕见的免疫介导性水疱大疱性疾病,据报道可由感染或药物诱发。阿替利珠单抗是一种靶向程序性细胞死亡配体1的单克隆抗体,已被用于治疗多种癌症。在此,我们报告1例使用阿替利珠单抗后发生药物性LABD的病例。

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本文引用的文献

1
Atezolizumab-induced linear IgA bullous dermatosis.阿替利珠单抗诱导的线状IgA大疱性皮肤病。
Br J Dermatol. 2022 Dec;187(6):e193. doi: 10.1111/bjd.21653. Epub 2022 Jun 7.
2
Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature.药物诱导的线性 IgA 大疱性皮病:病例报告及文献复习。
Acta Derm Venereol. 2019 May 1;99(6):508-515. doi: 10.2340/00015555-3154.
3
Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies.抗PD-1/PD-L1免疫检查点抗体的皮肤并发症
Curr Opin Oncol. 2016 Jul;28(4):254-63. doi: 10.1097/CCO.0000000000000290.
4
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.癌症患者对抗PD-L1抗体MPDL3280A反应的预测性相关因素。
Nature. 2014 Nov 27;515(7528):563-7. doi: 10.1038/nature14011.
5
Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells.与头孢曲松和甲硝唑特异性T细胞相关的药物性线状IgA大疱性皮肤病
Dermatology. 1999;199(1):25-30. doi: 10.1159/000018173.