Oheix Emmanuel, Daou T Jean, Pieuchot Laurent
Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute Alsace (UHA), CNRS, UMR 7361, 3 bis rue Alfred Werner, F-68093 Mulhouse, France.
Université de Strasbourg (UniStra), F-67000 Strasbourg, France.
Mater Horiz. 2024 Dec 9;11(24):6222-6256. doi: 10.1039/d4mh00259h.
The current surge in antibiotic resistance and the emergence of pandemics have created an urgent need for novel antimicrobial strategies. The controlled release of antimicrobial active principles remains the most viable strategy to date, and transition metal ions currently represent the main alternative to antibiotics. In this review, we explore the potential of two types of materials, zeolites and metal-organic frameworks (MOFs), for the controlled release of antimicrobial active principles, notably transition metal ions. These materials have unique crystalline microporous structures that act as reservoirs, enabling sustained bactericidal effects in various applications such as coatings, packaging, and medical devices. However, there are currently no convenient and standardised methods for evaluating their metal ion release and antimicrobial efficacy. This work discusses analytical techniques and the proposed mechanisms of action while highlighting recent advances in film, membrane, and coating technologies. By addressing the current limitations, microporous materials can revolutionise antimicrobial approaches, offering enhanced effectiveness and long-term sustainability.
当前抗生素耐药性的激增以及大流行病的出现，迫切需要新型抗菌策略。抗菌活性成分的控释仍然是迄今为止最可行的策略，过渡金属离子目前是抗生素的主要替代品。在本综述中，我们探讨了两种材料——沸石和金属有机框架（MOF）——用于控释抗菌活性成分（尤其是过渡金属离子）的潜力。这些材料具有独特的晶体微孔结构，可作为储存库，在涂层、包装和医疗设备等各种应用中实现持续的杀菌效果。然而，目前尚无方便且标准化的方法来评估它们的金属离子释放和抗菌效果。本文讨论了分析技术和提出的作用机制，同时突出了薄膜、膜和涂层技术的最新进展。通过解决当前的局限性，微孔材料可以彻底改变抗菌方法，提供更高的有效性和长期可持续性。
