Li Qinqin, Zhang Shihan, Xu Yachao, Guo Yaru, Liu Youxing
Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Adv Sci (Weinh). 2025 Jul;12(25):e2501327. doi: 10.1002/advs.202501327. Epub 2025 Apr 26.
The misuse of antibiotics results in the emergence of a large number of drug-resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal-organic frameworks (MOFs) (polyIn-BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn-BTB), polyIn-BTB exhibits a stronger electron-donating ability, which can facilitate the efficient production of ROS. Thus, polyIn-BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin-Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli) respectively, which is significantly higher than that of monoIn-BTB (42% for MRS. Aureus and 50% for E. coli). The in vivo experiments demonstrate that polyIn-BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn-BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance.
抗生素的滥用导致大量耐药菌的出现，这带来了巨大的经济和社会负担。探索人工纳米酶被认为是替代抗生素的有前途的候选方法，但仍然面临巨大挑战。在此，报道了一种构建多金属铟配位节点金属有机框架（MOFs）（聚铟-苯并三唑）以增强活性氧（ROS）产生的新策略，这显著促进了抗菌活性。理论研究表明，与单金属铟配位节点MOFs（单铟-苯并三唑）相比，聚铟-苯并三唑表现出更强的供电子能力，这可以促进ROS的高效产生。因此，聚铟-苯并三唑对耐甲氧西林金黄色葡萄球菌（MRS. aureus）和大肠杆菌（E. coli）分别表现出87.0%和92.0%的优异抗菌性能，显著高于单铟-苯并三唑（MRS. aureus为42%，E. coli为50%）。体内实验表明，聚铟-苯并三唑通过杀死细菌和抑制它们引起的炎症反应来加速伤口愈合，8天内伤口愈合率为98.0%。总体而言，这项工作报道了一种构建聚铟-苯并三唑以增强抗菌性能的新策略，为设计高性能纳米酶的基础研究打开了大门。
