Lee Shen-Han, Khoo Alan Soo-Beng, Griffiths John R, Mat Lazim Norhafiza
Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Int J Cancer. 2025 Feb 1;156(3):488-498. doi: 10.1002/ijc.35192. Epub 2024 Sep 18.
The Epstein-Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformation, but also utilises several non-cell autonomous mechanisms to shape the metabolic milieu in the tumour microenvironment (TME) and its constituent stromal and immune cells. In this review, we explore how EBV modulates metabolism to shape the interactions between cancer cells, stromal cells, and immune cells within a hypoxic and acidic TME. We highlight how metabolites resulting from EBV infection act as paracrine factors to regulate the TME, and how targeting them can disrupt barriers to immunotherapy.
爱泼斯坦-巴尔病毒（EBV）是首个被鉴定出的人类肿瘤病毒，全球超过95%的人都曾感染该病毒，它有可能诱发不同类型的癌症。人们越来越认识到，EBV感染不仅会改变细胞代谢，促进肿瘤转化，还会利用多种非细胞自主机制来塑造肿瘤微环境（TME）及其组成的基质细胞和免疫细胞中的代谢环境。在这篇综述中，我们探讨了EBV如何调节代谢，以塑造低氧和酸性TME中癌细胞、基质细胞和免疫细胞之间的相互作用。我们强调了EBV感染产生的代谢产物如何作为旁分泌因子来调节TME，以及针对这些代谢产物如何打破免疫治疗的障碍。
