Li Qiuyun, Liu Yuping, Chen Yong, Huang Yujuan, Deng Yayan, Fan Qianqing, Huang Lihong, Liu Xue, Ye Jiaxiang, Li Yongqiang, Wei Jiazhang, Zhang Jinyan
Department of Medical Oncology, Guangxi Medical University Cancer Hospital.
Department of Otolaryngology & Head and Neck, The People's Hospital of Guangxi Zhuang Autonomous Region.
Biol Pharm Bull. 2025;48(5):495-506. doi: 10.1248/bpb.b24-00872.
Epstein-Barr virus (EBV) is one of the most pervasive viruses worldwide, and EBV infection is inextricably linked to a multitude of lymphoid and epithelial neoplasms. EBV is responsible for the advancement of malignant disease by modifying the tumor microenvironment (TME), which is a sophisticated and evolving system that facilitates tumor growth, invasion, and metastasis. EBV infection has a profound impact on the cellular and noncellular components that constitute the TME. Our review presents a summary of the composition of the EBV-remodeled TME, with a particular focus on EBV-induced functional phenotypes in non-tumor cells. Furthermore, we discuss the potential for reversing EBV-driven TME remodeling as a therapeutic strategy for treating the malignancies associated with EBV infection.
爱泼斯坦-巴尔病毒（EBV）是全球最普遍的病毒之一，EBV感染与多种淋巴样和上皮性肿瘤密切相关。EBV通过改变肿瘤微环境（TME）推动恶性疾病的进展，肿瘤微环境是一个复杂且不断演变的系统，促进肿瘤生长、侵袭和转移。EBV感染对构成TME的细胞和非细胞成分有深远影响。我们的综述总结了EBV重塑的TME的组成，特别关注EBV在非肿瘤细胞中诱导的功能表型。此外，我们讨论了逆转EBV驱动的TME重塑作为治疗与EBV感染相关恶性肿瘤的治疗策略的潜力。
