Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ann Clin Transl Neurol. 2024 Nov;11(11):3031-3036. doi: 10.1002/acn3.52208. Epub 2024 Sep 18.
The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.
已有研究提示，评估显示中央静脉征（CVS）和顺磁性边缘病变（PRLs）的脑白质病变（WMLs）可增强成人多发性硬化（MS）的诊断。本研究旨在评估 22 例儿科 MS 患者中不同 CVS 标准的符合情况及 PRL 的附加价值。11 例（50%）患者符合 40%-规则阈值。19 例（86%）患者存在≥3 个 CVS+WMLs 或≥1 个 PRL，而 17 例（77%）患者存在≥6 个 CVS+WMLs 或≥1 个 PRL。在≥6 个 CVS+WMLs 的患者中，采用基于 CVS 的简化方法，结合评估≥1 个 PRL，可能有助于儿科患者 MS 的诊断。
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