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评估儿童多发性硬化症中的中央静脉征和顺磁性边缘病变。

Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis.

机构信息

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Ann Clin Transl Neurol. 2024 Nov;11(11):3031-3036. doi: 10.1002/acn3.52208. Epub 2024 Sep 18.

DOI:10.1002/acn3.52208
PMID:39291789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572724/
Abstract

The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.

摘要

已有研究提示，评估显示中央静脉征（CVS）和顺磁性边缘病变（PRLs）的脑白质病变（WMLs）可增强成人多发性硬化（MS）的诊断。本研究旨在评估 22 例儿科 MS 患者中不同 CVS 标准的符合情况及 PRL 的附加价值。11 例（50%）患者符合 40%-规则阈值。19 例（86%）患者存在≥3 个 CVS+WMLs 或≥1 个 PRL，而 17 例（77%）患者存在≥6 个 CVS+WMLs 或≥1 个 PRL。在≥6 个 CVS+WMLs 的患者中，采用基于 CVS 的简化方法，结合评估≥1 个 PRL，可能有助于儿科患者 MS 的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14a4/11572724/8998feffc515/ACN3-11-3031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14a4/11572724/8998feffc515/ACN3-11-3031-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14a4/11572724/8998feffc515/ACN3-11-3031-g001.jpg

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本文引用的文献

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Brain. 2024 Sep 3;147(9):2913-2933. doi: 10.1093/brain/awae013.
2
The diagnostic value of the central vein sign in radiologically isolated syndrome.中央静脉征在放射孤立综合征中的诊断价值。
Ann Clin Transl Neurol. 2024 Mar;11(3):662-672. doi: 10.1002/acn3.51986. Epub 2024 Jan 8.
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A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis.一项评估简化中心静脉评估用于多发性硬化症诊断的多中心试点研究。
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Central Vein Sign in Pediatric Multiple Sclerosis and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.儿童多发性硬化症和髓鞘少突胶质细胞糖蛋白抗体相关疾病的中央静脉征。
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Paramagnetic rim and core sign lesions in paediatric multiple sclerosis patients.儿童多发性硬化症患者的顺磁性边缘和核心征病变
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Neurology. 2023 Jan 17;100(3):e308-e323. doi: 10.1212/WNL.0000000000201465. Epub 2022 Oct 3.
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