评估儿童多发性硬化症中的中央静脉征和顺磁性边缘病变。
Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis.
机构信息
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
出版信息
Ann Clin Transl Neurol. 2024 Nov;11(11):3031-3036. doi: 10.1002/acn3.52208. Epub 2024 Sep 18.
The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.
已有研究提示，评估显示中央静脉征（CVS）和顺磁性边缘病变（PRLs）的脑白质病变（WMLs）可增强成人多发性硬化（MS）的诊断。本研究旨在评估 22 例儿科 MS 患者中不同 CVS 标准的符合情况及 PRL 的附加价值。11 例（50%）患者符合 40%-规则阈值。19 例（86%）患者存在≥3 个 CVS+WMLs 或≥1 个 PRL，而 17 例（77%）患者存在≥6 个 CVS+WMLs 或≥1 个 PRL。在≥6 个 CVS+WMLs 的患者中，采用基于 CVS 的简化方法，结合评估≥1 个 PRL，可能有助于儿科患者 MS 的诊断。
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