Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21205, USA.
Johns Hopkins School of Medicine, Baltimore, MD, USA.
Eur J Epidemiol. 2024 Sep;39(9):1051-1062. doi: 10.1007/s10654-024-01147-z. Epub 2024 Sep 18.
The Johns Hopkins HIV Clinical Cohort, established in 1989, links comprehensive, longitudinal clinical data for adults with HIV receiving care in the Johns Hopkins John G. Bartlett Specialty Practice in Baltimore, Maryland, USA, to aid in understanding HIV care and treatment outcomes. Data include demographics, laboratory results, inpatient and outpatient visit information and clinical diagnoses, and prescribed and dispensed medications abstracted from medical records. A subset of patients separately consents to self-report patient-centric outcomes on standardized instruments approximately every 6 months, and another subset separately consents to contribute plasma and peripheral blood mononuclear cells to a linked specimen repository approximately annually. The cohort has cumulatively enrolled over 8000 people, with just under 2000 on average attending ≥ 1 HIV primary care visit in any given year. The cohort reflects the HIV epidemic in Baltimore: in 2021, median age was 57, 64% of participants were male, 77% were non-Hispanic Black, and 37% acquired HIV through injection drug use. This update to the cohort profile of the Johns Hopkins HIV Clinical Cohort illustrates both how the population of people with HIV in Baltimore, Maryland, USA has changed over three decades, and we have adapted data collection procedures over three decades to ensure this long-running cohort remains responsive to patient characteristics and research gaps in the provision of care to people with HIV and substance use.
约翰霍普金斯艾滋病毒临床队列成立于 1989 年，将美国马里兰州巴尔的摩市约翰霍普金斯约翰 G.巴特利特专业实践中接受艾滋病毒治疗的成年人的全面、纵向临床数据联系起来，以帮助了解艾滋病毒护理和治疗结果。数据包括人口统计学信息、实验室结果、住院和门诊就诊信息和临床诊断，以及从病历中提取的处方和配发药物。一小部分患者分别同意每隔大约 6 个月使用标准化工具报告以患者为中心的结果，另一小部分患者则分别同意每年向一个关联的标本库捐献血浆和外周血单核细胞。该队列累计入组了 8000 多人，平均每年有近 2000 人至少参加 1 次艾滋病毒初级保健就诊。该队列反映了巴尔的摩的艾滋病毒流行情况：2021 年，中位年龄为 57 岁，64%的参与者为男性，77%为非西班牙裔黑人，37%通过注射吸毒感染艾滋病毒。本更新版约翰霍普金斯艾滋病毒临床队列简介说明了美国马里兰州巴尔的摩市的艾滋病毒感染者群体在过去三十年中发生的变化，以及我们在过去三十年中如何调整数据收集程序，以确保这个长期运行的队列仍然能够响应艾滋病毒感染者和药物滥用者护理提供方面的患者特征和研究空白。
