Li Jingwen, Li Shumei, Zeng Shaoqin, Wang Xinzhi, Liu Mengchen, Xu Guang, Ma Xiaofen
Department of Nuclear Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Road XinGang, Guangzhou, 510317, P. R. China.
Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Road XinGang, Guangzhou, 510317, P. R. China.
Brain Imaging Behav. 2024 Dec;18(6):1385-1393. doi: 10.1007/s11682-024-00928-0. Epub 2024 Sep 18.
Several studies have revealed altered intrinsic neural activity in chronic insomnia (CI). However, the temporal variability of intrinsic neural activity in CI is rarely mentioned. This study aimed to explore static and temporal dynamic alterations of regional homogeneity (ReHo) in CI and excavate the potential associations between these changes and clinical characteristics. Eighty-seven patients with CI and seventy-eight healthy controls (HCs) were included. Resting-state functional magnetic resonance imaging was performed on all subjects and both static and dynamic ReHo were used to detect local functional connectivity. We then tested the relationship between altered brain regions, disease duration, and clinical scales. The receiver operating characteristic curve analysis was used to reveal the potential capability of these indicators to screen CI patients from HCs. CI showed increased dynamic ReHo in the right precuneus and decreased static ReHo in the right cerebellum_6. The dynamic ReHo values of the right precuneus were negatively correlated with the self-rating depression score and the static ReHo values of the right cerebellum_6 were positively correlated with the Montreal Cognitive Assessment-Naming score. In addition, the combination of the two metrics showed a potential capacity to distinguish CI patients from HCs, which was better than a single metric alone. The present study has revealed the altered local functional connectivity under static and temporal dynamic conditions in patients with CI, and found the relationships between these changes, mood-related scales, and cognitive-related scales. These may be useful in elucidating the neurological mechanisms of CI and accompanying symptoms.
多项研究揭示了慢性失眠（CI）患者内在神经活动的改变。然而，CI患者内在神经活动的时间变异性却鲜有提及。本研究旨在探讨CI患者局部一致性（ReHo）的静态和时间动态变化，并挖掘这些变化与临床特征之间的潜在关联。研究纳入了87例CI患者和78名健康对照者（HCs）。对所有受试者进行静息态功能磁共振成像检查，采用静态和动态ReHo检测局部功能连接。然后我们测试了脑区改变、病程和临床量表之间的关系。采用受试者工作特征曲线分析来揭示这些指标从HCs中筛选出CI患者的潜在能力。CI患者右侧楔前叶动态ReHo增加，右侧小脑_6静态ReHo降低。右侧楔前叶的动态ReHo值与自评抑郁量表得分呈负相关，右侧小脑_6的静态ReHo值与蒙特利尔认知评估-命名量表得分呈正相关。此外，这两个指标的组合显示出区分CI患者和HCs的潜在能力，且优于单一指标。本研究揭示了CI患者在静态和时间动态条件下局部功能连接的改变，并发现了这些变化与情绪相关量表和认知相关量表之间的关系。这些可能有助于阐明CI及其伴随症状的神经机制。
