Perry T L, Hansen S
Psychiatry Res. 1985 Jun;15(2):109-13. doi: 10.1016/0165-1781(85)90046-0.
Fasting plasma serine and glycine concentrations, determined by ion-exchange amino acid chromatography, were similar in a large group of psychotic patients with various forms of schizophrenia and in healthy control subjects. Serine and glycine concentrations were also similar in cerebrospinal fluid of psychotic patients and control subjects. The contents of serine and glycine in autopsied brain of three patients with chronic schizophrenia did not differ from contents of these amino acids in control subjects when analyses were limited to brains frozen rapidly after death. These data do not support a recent suggestion (Waziri et al., 1984) that disturbed serine metabolism may be a biological marker and a vulnerability factor for psychosis.
通过离子交换氨基酸色谱法测定，一大群患有各种形式精神分裂症的精神病患者和健康对照者的空腹血浆丝氨酸和甘氨酸浓度相似。精神病患者和对照者脑脊液中的丝氨酸和甘氨酸浓度也相似。当分析仅限于死后迅速冷冻的大脑时，三名慢性精神分裂症患者尸检大脑中丝氨酸和甘氨酸的含量与对照者这些氨基酸的含量没有差异。这些数据不支持最近的一项建议（瓦齐里等人，1984年），即丝氨酸代谢紊乱可能是精神病的生物学标志物和易患因素。
