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减重手术与广泛门静脉血栓形成之间的关联:一例报告。

The association between bariatric surgery and extensive portal vein thrombosis: A case report.

作者信息

Meng Muzi, Pradhan Jigyasha, Singh Ajit

机构信息

General Surgery, BronxCare Health System, Bronx, NY, USA; School of Medicine, American University of the Caribbean, Cupecoy, Sint Maarten (Dutch Part).

General Surgery, BronxCare Health System, Bronx, NY, USA.

出版信息

Int J Surg Case Rep. 2024 Oct;123:110276. doi: 10.1016/j.ijscr.2024.110276. Epub 2024 Sep 10.

DOI:10.1016/j.ijscr.2024.110276
PMID:39293223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11424933/
Abstract

INTRODUCTION AND IMPORTANCE

As the obesity rate continues to rise, portal vein thrombosis (PVT) has emerged as a more frequent complication following bariatric surgery, with an incidence reported at approximately 0.4 % according to recent meta-analyses. PVT, characterized by the development of a thrombus within the portal vein, can be life-threatening due to its subtle and often nonspecific symptoms, complicating timely diagnosis and treatment.

CASE PRESENTATION

In this case report, we present a 45-year-old female patient with a history of morbid obesity who underwent robotic-assisted laparoscopic sleeve gastrectomy and hiatal hernia repair. On postoperative day 16, she developed symptoms of severe abdominal pain and intolerance to oral intake, suggesting the presence of portal vein thrombosis. Laboratory findings showed significantly elevated D-dimer levels, and contrast-enhanced CT imaging confirmed an extensive thrombus within the portal vein. The patient was promptly admitted to the critical care unit, where she was managed conservatively with therapeutic anticoagulation, including subcutaneous heparin preoperatively and postoperatively, and discharged with a prescription for apixaban.

CLINICAL DISCUSSION

Early diagnosis of PVT in the post-bariatric population is critical, as it allows for timely intervention with evidence-based therapeutic options such as anticoagulation, thereby improving both short- and long-term patient outcomes. This case not only underscores the importance of heightened vigilance for PVT in patients presenting with nonspecific abdominal symptoms after bariatric surgery but also highlights the potential risk factors unique to this patient, such as prolonged operative time and underlying comorbidities, which may have contributed to the thrombotic event. A multidisciplinary approach, involving both medical and surgical teams, is essential for optimal management of such complex cases.

CONCLUSION

This case underscores the critical importance of early recognition and prompt management of portal vein thrombosis in post-bariatric surgery patients. By emphasizing the role of thorough perioperative DVT prophylaxis, including the use of heparin and sequential compression devices, this report not only aims to improve patient outcomes but also contributes to the growing body of knowledge on the prevention and treatment of PVT in the bariatric population. These insights may serve as a valuable framework for managing similar clinical scenarios in the future.

摘要

引言与重要性

随着肥胖率持续上升,门静脉血栓形成(PVT)已成为减肥手术后更常见的并发症,根据最近的荟萃分析,其发生率约为0.4%。PVT的特征是门静脉内形成血栓,由于其症状隐匿且往往不具特异性,可能危及生命,使及时诊断和治疗变得复杂。

病例介绍

在本病例报告中,我们介绍了一名45岁的女性患者,她有病态肥胖史,接受了机器人辅助腹腔镜袖状胃切除术和食管裂孔疝修补术。术后第16天,她出现严重腹痛和不耐受口服摄入的症状,提示存在门静脉血栓形成。实验室检查结果显示D-二聚体水平显著升高,增强CT成像证实门静脉内有广泛血栓。患者立即被收入重症监护病房,在那里接受了包括术前和术后皮下注射肝素在内的抗凝治疗,并出院时开具了阿哌沙班处方。

临床讨论

减肥后人群中PVT的早期诊断至关重要,因为这允许及时采用基于证据的治疗选择(如抗凝)进行干预,从而改善患者的短期和长期预后。该病例不仅强调了对减肥手术后出现非特异性腹部症状的患者提高对PVT警惕性的重要性,还突出了该患者特有的潜在风险因素,如手术时间延长和潜在合并症,这些因素可能导致了血栓形成事件。多学科方法,包括医疗和手术团队,对于此类复杂病例的最佳管理至关重要。

结论

本病例强调了减肥手术后患者早期识别和及时处理门静脉血栓形成的至关重要性。通过强调全面的围手术期深静脉血栓预防的作用,包括使用肝素和序贯加压装置,本报告不仅旨在改善患者预后,还为减肥人群中PVT的预防和治疗知识的不断增长做出贡献。这些见解可能成为未来管理类似临床情况的宝贵框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/11424933/40d3e2b7f731/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/11424933/e9499a31f9b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/11424933/40d3e2b7f731/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/11424933/e9499a31f9b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1799/11424933/40d3e2b7f731/gr2.jpg

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Portal Vein Thrombosis: State-of-the-Art Review.门静脉血栓形成:最新综述
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Portal vein thrombosis in cirrhosis: A literature review.肝硬化门静脉血栓形成:文献综述
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