Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
Clin Exp Ophthalmol. 2017 Dec;45(9):884-893. doi: 10.1111/ceo.12986. Epub 2017 Jun 15.
Identifying changes of peripapillary vessel density in highly myopic eyes with peripapillary intrachoroidal cavitation by optical coherence tomography angiography.
To investigate peripapillary vessel density and its relationship with other ocular parameters in highly myopic eyes with peripapillary intrachoroidal cavitation.
Hospital-based, cross-sectional study.
Thirty-five highly myopic eyes with peripapillary intrachoroidal cavitation, 46 highly myopic eyes without peripapillary intrachoroidal cavitation and 36 normal eyes were included in this study.
All participants underwent optical coherence tomography angiography to image the retinal vasculature in the peripapillary areas, including the radial peripapillary capillaries and optic nerve head layer. Correlations between vessel density and ocular metrics were analysed.
Peripapillary vessel density.
In highly myopic eyes, vessel density was significantly lower in eyes with peripapillary intrachoroidal cavitation than in those without in peripapillary (P = 0.014, P = 0.037), inferotemporal (P < 0.001, P < 0.001) and superotemporal (P = 0.014, P = 0.009) areas. In the radial peripapillary capillaries layer, vessel density was negatively correlated with peripapillary atrophy area (P = 0.012) and myopic maculopathy (P = 0.002), and in the optic nerve head layer, it was negatively associated with a diagnosis of peripapillary intrachoroidal cavitation (P = 0.012) and myopic maculopathy (P < 0.001). In addition, it was positively correlated with retinal nerve fibre layer thickness in both layers (P < 0.001).
Highly myopic eyes with peripapillary intrachoroidal cavitation had lower peripapillary vessel densities, especially in the temporal area, than those without.
通过光相干断层扫描血管造影术识别高度近视伴脉络膜周围腔隙性病变的视盘周围血管密度变化。
研究高度近视伴脉络膜周围腔隙性病变的视盘周围血管密度及其与其他眼部参数的关系。
基于医院的横断面研究。
本研究共纳入 35 只高度近视伴脉络膜周围腔隙性病变的眼、46 只高度近视不伴脉络膜周围腔隙性病变的眼和 36 只正常眼。
所有参与者均接受光相干断层扫描血管造影术，以对视盘周围区域的视网膜血管成像，包括放射状视盘毛细血管和视神经头层。分析血管密度与眼部指标的相关性。
视盘周围血管密度。
在高度近视眼中，脉络膜周围腔隙性病变眼的视盘周围血管密度明显低于无病变眼，在视盘周围（P = 0.014，P = 0.037）、下颞（P < 0.001，P < 0.001）和上颞（P = 0.014，P = 0.009）区域。在放射状视盘毛细血管层，血管密度与视盘周围萎缩面积（P = 0.012）和近视性黄斑病变（P = 0.002）呈负相关，在视神经头层，与脉络膜周围腔隙性病变的诊断（P = 0.012）和近视性黄斑病变（P < 0.001）呈负相关。此外，它与两个层面的视网膜神经纤维层厚度呈正相关（P < 0.001）。
与无脉络膜周围腔隙性病变的高度近视眼相比，高度近视伴脉络膜周围腔隙性病变眼的视盘周围血管密度较低，特别是在颞侧区域。
