Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Diabetes Obes Metab. 2024 Dec;26(12):5621-5629. doi: 10.1111/dom.15929. Epub 2024 Sep 18.
To investigate the relationship between the weight-adjusted-waist index (WWI) and all-cause mortality as well as cardiovascular mortality in individuals with type 2 diabetes.
We used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 and the UK Biobank database. Restricted cubic spline curves and Cox proportional hazards models were employed to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality.
In the UK Biobank database, compared with the lowest WWI quartile, the HR for all-cause and cardiovascular death in the highest quartile was 1.846 (95% CI 1.687-2.019) and 2.118 (95% CI 1.783-2.517), respectively, in the fully adjusted model. In the NHANES database, compared with the lowest WWI quartile, the highest quartile had an HR of 1.727 (95% CI 1.378-2.163) for all-cause death and 1.719 (95% CI 1.139-2.595) for cardiovascular death in the fully adjusted model.
Our study indicates that WWI has a long-term synergistic negative impact on all-cause mortality and cardiovascular mortality in individuals with type 2 diabetes. The WWI is an independent predictor of mortality in individuals with type 2 diabetes.
探讨体重调整腰围指数（WWI）与 2 型糖尿病患者全因死亡率和心血管死亡率之间的关系。
我们使用了 1999 年至 2018 年全国健康和营养调查（NHANES）和英国生物库数据库的数据。采用限制性三次样条曲线和 Cox 比例风险模型评估全因死亡率的风险比（HR）和 95%置信区间（CI）。
在英国生物库数据库中，与最低 WWI 四分位相比，最高四分位的全因和心血管死亡的 HR 在完全调整模型中分别为 1.846（95%CI 1.687-2.019）和 2.118（95%CI 1.783-2.517）。在 NHANES 数据库中，与最低 WWI 四分位相比，最高四分位的全因死亡 HR 为 1.727（95%CI 1.378-2.163），心血管死亡 HR 为 1.719（95%CI 1.139-2.595），均在完全调整模型中。
本研究表明，WWI 对 2 型糖尿病患者的全因死亡率和心血管死亡率有长期的协同负面影响。WWI 是 2 型糖尿病患者死亡率的独立预测因子。
