Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Department of Otolaryngology-Head and Neck Surgery, Anshun People's Hospital, Anshun, Guizhou Province, China.
J Oral Pathol Med. 2024 Oct;53(9):584-594. doi: 10.1111/jop.13579. Epub 2024 Sep 18.
Platelet-derived growth factor A (PDGFA) has been shown to be upregulated in several tumors, contributing to their malignant phenotypes. However, its expression and function in head and neck squamous cell carcinoma (HNSC) are not clearly understood. Thus, we aimed to evaluate this issue using bioinformatic analyses and primary experimental validation.
The expression of PDGFA was analyzed using popular bio-databases and further validated by RT-PCR and immunohistochemical staining. Survival analyses were then performed. The association between PDGFA expression levels and immune cell infiltration in the immune microenvironment was assessed.
PDGFA has been found to be significantly upregulated in a variety of cancers, including HNSC, and increased PDGFA expression may be an independent prognostic factor associated with immune cell infiltration in HNSC.
Overexpression of PDGFA in HNSC is significantly associated with poor prognosis and immune cell infiltration in the tumor microenvironment (TME). PDGFA has potential as a molecular indicator for diagnosis, prognosis, and immune processes in HNSC.
血小板衍生生长因子 A（PDGFA）在多种肿瘤中呈上调表达，有助于其恶性表型。然而，其在头颈部鳞状细胞癌（HNSC）中的表达和功能尚不清楚。因此，我们旨在使用生物信息学分析和初步实验验证来评估这一问题。
使用流行的生物数据库分析 PDGFA 的表达，并通过 RT-PCR 和免疫组织化学染色进一步验证。然后进行生存分析。评估 PDGFA 表达水平与免疫微环境中免疫细胞浸润的相关性。
PDGFA 在多种癌症中呈显著上调表达，包括 HNSC，并且 PDGFA 表达增加可能是与 HNSC 中免疫细胞浸润相关的独立预后因素。
HNSC 中 PDGFA 的过表达与肿瘤微环境（TME）中的不良预后和免疫细胞浸润显著相关。PDGFA 有望成为 HNSC 中诊断、预后和免疫过程的分子指标。
